Biocatalytic preparation of a chiral synthon for a vasopeptidase inhibitor: enzymatic conversion of N super(2)-[N-Phenylmethoxy)carbonyl] L-homocysteinyl]- L-lysine (1- > 1')-disulfide to [4S-(4I,7I,10aJ)] 1-octahydro-5-oxo-4-[phenylmethoxy)carbonyl]amino]-7H-pyrido-[2,1- b] [1,3]thiazepine-7-carboxylic acid methyl ester by a novel L-lysine epsilon -aminotransferase

[4S-(4I,7I,10aJ)]1-Octahydro-5-oxo-4-[phenylmethoxy) carbonyl]amino]-7H-pyrido-[2,1-b] [1,3]thiazepine-7-carboxylic acid methyl ester (BMS-199541-01) is a key chiral intermediate for the synthesis of Omapatrilat (BMS-186716), a new vasopeptidease inhibitor under development. By using a selective enr...

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Veröffentlicht in:	Enzyme and microbial technology 2000-09, Vol.27 (6), p.376-389
Hauptverfasser:	Patel, R N, Banerjee, A, Nanduri, V B, Goldberg, S L, Johnston, R M, Hanson, R L, McNamee, C G, Brzozowski, D B, Tully, T P, Ko, R Y, LaPorte, T L, Cazzulino, DL, Swaminathan, S, Chen, C-K
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Animal cell culture Bioconversion Biosynthesis Carboxylic acids Catalyst activity Genetic engineering L-Lysine ^e-aminotransferase Oxidation Polypeptides Purification Sphingomonas paucimobilis Streptomyces noursei vasopeptidase
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