Computer model for glucose-limited growth of a single cell of Escherichia coli B/r-A
A computer model is described which is capable of predicting changes in cell composition, cell size, cell shape, and the timing of chromosome synthesis in response to changes in external glucose limitation. The model is constructed primarily from information on unrestricted growth in glucose minimal...
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| Veröffentlicht in: | Biotechnology and bioengineering 2000-03, Vol.67 (6), p.827-840 |
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| container_title | Biotechnology and bioengineering |
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| creator | Domach, M. M. Leung, S. K. Cahn, R. E. Cocks, G. G. Shuler, M. L. |
| description | A computer model is described which is capable of predicting changes in cell composition, cell size, cell shape, and the timing of chromosome synthesis in response to changes in external glucose limitation. The model is constructed primarily from information on unrestricted growth in glucose minimal medium. The ability of the model to make reasonable quantitative predictions under glucose‐limitation is a test of the plausibility of the basic biochemical mechanisms included in the model. Such a model should be of use in differentiating among competing hypotheses for biological mechanisms and in suggesting as yet unobserved phenomena. The last two points are illustrated with the testing of a mechanism for the control of the initiation of DNA synthesis and predictions on cell‐width variations during the division cycle. |
| doi_str_mv | 10.1002/(SICI)1097-0290(20000320)67:6<827::AID-BIT18>3.0.CO;2-N |
| format | Article |
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Such a model should be of use in differentiating among competing hypotheses for biological mechanisms and in suggesting as yet unobserved phenomena. The last two points are illustrated with the testing of a mechanism for the control of the initiation of DNA synthesis and predictions on cell‐width variations during the division cycle.</description><subject>Biochemistry</subject><subject>Biosynthesis</subject><subject>DNA</subject><subject>Escherichia coli</subject><subject>Glucose</subject><subject>Growth kinetics</subject><subject>Mathematical models</subject><issn>0006-3592</issn><issn>1097-0290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNo9kN1v0zAUxS0EEmXwP_gJbQ_u_BHbSUGgLvuK6NqHFY23qyixW4MzFzvVtv9-yQq7L1f36Jyjqx9C3xmdMkr56fFtVVYnjBaaUF7QY06HEZyeKD1TX3OuZ7N5dU7OqjXLv4kpnZarL5ws36DJa-YtmgwZRYQs-Hv0IaXfw6lzpSZoXYZut-9NxF1ojcc2RLzx-yYkQ7zrXG9avInhod_iYHGNk7vfeIMb4_0oXKRma6Jrtq7GTfAOn51GMv-I3tnaJ_Pp3z5CPy8v1uU1WayuqnK-II4LmZOcqVpLkbFCap5nSgmpi9y2NrNtpgzjdUsLWbRFZjVvsky2lreyYTQ3rLFaiSP0-dC7i-Hv3qQeOpfG1-p7E_YJOMuYpIwPxl8H44Pz5gl20XV1fAJGYUQMI2EYacFIC_4TBqVBwUAYBsDwAhgEUChXwGF5EIZqcqh2qTePr9V1_DPEhZZwt7yCH3eLa3kjJFyKZwqIg2E</recordid><startdate>20000320</startdate><enddate>20000320</enddate><creator>Domach, M. 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| ispartof | Biotechnology and bioengineering, 2000-03, Vol.67 (6), p.827-840 |
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| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals |
| subjects | Biochemistry Biosynthesis DNA Escherichia coli Glucose Growth kinetics Mathematical models |
| title | Computer model for glucose-limited growth of a single cell of Escherichia coli B/r-A |
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