Protective role of metallothionein in benzo[a]pyrene-induced DNA damage

Metallothionein (MT) is known to reduce chemical carcinogenesis. Carcinogenesis induced by benzo[a]pyrene (B[a]P) which is an environmental chemical carcinogen is related to DNA adduct formation and oxidative damage through metabolic activation. Ten-week-old male MT-I/II null mice and wild-type mice...

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Veröffentlicht in:	Journal of toxicological sciences 2009/10/01, Vol.34(5), pp.449-458
Hauptverfasser:	Takaishi, Masaki, Sawada, Masumi, Shimada, Akinori, Suzuki, Junko S., Satoh, Masahiko, Nagase, Hisamitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	8-OHdG Animals B[a]P Benzo(a)pyrene Benzo(a)pyrene - toxicity Bioindicators biomarkers Carcinogenesis Carcinogens Carcinogens, Environmental - toxicity Comet assay CYP1A protein Cytochrome Cytochrome P-450 CYP1A1 - metabolism Cytochrome P450 Deoxyguanosine - metabolism DNA DNA adducts DNA damage DNA Damage - drug effects EROD activity Immunohistochemistry Liver Liver - metabolism Male Metabolic activation Metallothionein Metallothionein - metabolism metallothioneins Mice Micronucleus test Mutagenicity Tests Reticulocytes
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