Pulsed Ultrasounds Reduce Pain and Disability, Increasing Rib Fracture Healing, in a Randomized Controlled Trial
Rib fractures are an important health issue worldwide, with significant, pain, morbidity, and disability for which only symptomatic treatment exists. Based on our previous experimental model, the objective of the current study was to assess for the first time whether pulsed ultrasound (PUS) applicat...
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| Veröffentlicht in: | Pain medicine (Malden, Mass.) Mass.), 2019-10, Vol.20 (10), p.1980-1988 |
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| container_end_page | 1988 |
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| container_title | Pain medicine (Malden, Mass.) |
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| creator | Santana-Rodríguez, Norberto Clavo, Bernardino Llontop, Pedro Fiuza, María D Calatayud-Gastardi, Joaquín López, Daniel López-Fernández, Daniel Aguiar-Santana, Ione A Ayub, Adil Alshehri, Khalid Jordi, Nagib A Zubeldia, José Bröering, Dieter C |
| description | Rib fractures are an important health issue worldwide, with significant, pain, morbidity, and disability for which only symptomatic treatment exists.
Based on our previous experimental model, the objective of the current study was to assess for the first time whether pulsed ultrasound (PUS) application could have beneficial effects on humans.
Prospective, double-blinded, randomized, controlled trial of 51 patients. Four were excluded, and 47 were randomized into the control group (N = 23) or PUS group (N = 24). The control group received a PUS procedure without emission, and the PUS group received 1 Mhz, 0.5 W/cm2 for 1 min/cm2. Pain level, bone callus healing rate, physical and work activity, pain medication intake, and adverse events were blindly evaluated at baseline and one, three, and six months.
There were no significant differences at baseline between groups. PUS treatment significantly decreased pain by month 1 (P = 0.004), month 3 (P = 0.005), and month 6 (P = 0.025), significantly accelerated callus healing by month 1 (P = 0.013) and month 3 (P |
| doi_str_mv | 10.1093/pm/pny224 |
| format | Article |
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Based on our previous experimental model, the objective of the current study was to assess for the first time whether pulsed ultrasound (PUS) application could have beneficial effects on humans.
Prospective, double-blinded, randomized, controlled trial of 51 patients. Four were excluded, and 47 were randomized into the control group (N = 23) or PUS group (N = 24). The control group received a PUS procedure without emission, and the PUS group received 1 Mhz, 0.5 W/cm2 for 1 min/cm2. Pain level, bone callus healing rate, physical and work activity, pain medication intake, and adverse events were blindly evaluated at baseline and one, three, and six months.
There were no significant differences at baseline between groups. PUS treatment significantly decreased pain by month 1 (P = 0.004), month 3 (P = 0.005), and month 6 (P = 0.025), significantly accelerated callus healing by month 1 (P = 0.013) and month 3 (P < 0.001), accelerated return to physical activity by month 3 (P = 0.036) and work activity (P = 0.001) by month 1, and considerably reduced pain medication intake by month 1 (P = 0.057) and month 3 (P = 0.017). No related adverse events were found in the PUS group.
This study is the first evidence that PUS treatment is capable of improving rib fracture outcome, significantly accelerating bone callus healing, and decreasing pain, time off due to both physical activity and convalescence period, and pain medication intake. It is a safe, efficient, and low-cost therapy that may become a new treatment for patients with stable rib fractures.</description><identifier>ISSN: 1526-2375</identifier><identifier>EISSN: 1526-4637</identifier><identifier>DOI: 10.1093/pm/pny224</identifier><identifier>PMID: 30496510</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Analgesics ; Analysis ; Bone healing ; Callus ; Care and treatment ; Convalescence ; Exercise ; Fractures ; Health aspects ; Morbidity ; Pain ; Physical activity ; Rib ; Rib cage ; Ultrasonic imaging ; Ultrasound</subject><ispartof>Pain medicine (Malden, Mass.), 2019-10, Vol.20 (10), p.1980-1988</ispartof><rights>2018 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>COPYRIGHT 2019 Oxford University Press</rights><rights>2018 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-ca53faa9b91f8a2bfc349fa6172da959e2c2566245fdd18248f95a42b28a2b213</citedby><cites>FETCH-LOGICAL-c380t-ca53faa9b91f8a2bfc349fa6172da959e2c2566245fdd18248f95a42b28a2b213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30496510$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santana-Rodríguez, Norberto</creatorcontrib><creatorcontrib>Clavo, Bernardino</creatorcontrib><creatorcontrib>Llontop, Pedro</creatorcontrib><creatorcontrib>Fiuza, María D</creatorcontrib><creatorcontrib>Calatayud-Gastardi, Joaquín</creatorcontrib><creatorcontrib>López, Daniel</creatorcontrib><creatorcontrib>López-Fernández, Daniel</creatorcontrib><creatorcontrib>Aguiar-Santana, Ione A</creatorcontrib><creatorcontrib>Ayub, Adil</creatorcontrib><creatorcontrib>Alshehri, Khalid</creatorcontrib><creatorcontrib>Jordi, Nagib A</creatorcontrib><creatorcontrib>Zubeldia, José</creatorcontrib><creatorcontrib>Bröering, Dieter C</creatorcontrib><title>Pulsed Ultrasounds Reduce Pain and Disability, Increasing Rib Fracture Healing, in a Randomized Controlled Trial</title><title>Pain medicine (Malden, Mass.)</title><addtitle>Pain Med</addtitle><description>Rib fractures are an important health issue worldwide, with significant, pain, morbidity, and disability for which only symptomatic treatment exists.
Based on our previous experimental model, the objective of the current study was to assess for the first time whether pulsed ultrasound (PUS) application could have beneficial effects on humans.
Prospective, double-blinded, randomized, controlled trial of 51 patients. Four were excluded, and 47 were randomized into the control group (N = 23) or PUS group (N = 24). The control group received a PUS procedure without emission, and the PUS group received 1 Mhz, 0.5 W/cm2 for 1 min/cm2. Pain level, bone callus healing rate, physical and work activity, pain medication intake, and adverse events were blindly evaluated at baseline and one, three, and six months.
There were no significant differences at baseline between groups. PUS treatment significantly decreased pain by month 1 (P = 0.004), month 3 (P = 0.005), and month 6 (P = 0.025), significantly accelerated callus healing by month 1 (P = 0.013) and month 3 (P < 0.001), accelerated return to physical activity by month 3 (P = 0.036) and work activity (P = 0.001) by month 1, and considerably reduced pain medication intake by month 1 (P = 0.057) and month 3 (P = 0.017). No related adverse events were found in the PUS group.
This study is the first evidence that PUS treatment is capable of improving rib fracture outcome, significantly accelerating bone callus healing, and decreasing pain, time off due to both physical activity and convalescence period, and pain medication intake. It is a safe, efficient, and low-cost therapy that may become a new treatment for patients with stable rib fractures.</description><subject>Analgesics</subject><subject>Analysis</subject><subject>Bone healing</subject><subject>Callus</subject><subject>Care and treatment</subject><subject>Convalescence</subject><subject>Exercise</subject><subject>Fractures</subject><subject>Health aspects</subject><subject>Morbidity</subject><subject>Pain</subject><subject>Physical activity</subject><subject>Rib</subject><subject>Rib cage</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><issn>1526-2375</issn><issn>1526-4637</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkctqHDEQRUVIiF9Z5AeCIJsYPLbe0700kzg2GGIGey2q1ZKRUUsdqXsx_vpomIlJjNFCRXHuraIuQp8pOaek5RfjcDHGDWPiHTqkkqmFUHz5fl8zvpQH6KiUJ0KoEg3_iA44Ea2SlByi8W4Oxfb4IUwZSppjX_Da9rOx-A58xBB7_N0X6Hzw0-YM30STLRQfH_Had_gqg5nmbPG1hVCbZ3irwesqS4N_rsarFKecQqjlffYQTtAHB3Xkp_1_jB6uftyvrhe3v37erC5vF4Y3ZFoYkNwBtF1LXQOsc4aL1oGiS9ZDK1vLDJNKMSFd39OGica1EgTr2JZmlB-jbzvfMaffsy2THnwxNgSINs1FMyookURyUtGvr9CnNOdYt9OMK8Hq2dQ_1CMEq310qV7MbE31paKKUylEW6nzN6j6ejt4k6J1vvb_E5zuBCanUrJ1esx-gLzRlOhtunoc9C7dyn7ZLzp3g-1fyL9x8j9qNp5c</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Santana-Rodríguez, Norberto</creator><creator>Clavo, Bernardino</creator><creator>Llontop, Pedro</creator><creator>Fiuza, María D</creator><creator>Calatayud-Gastardi, Joaquín</creator><creator>López, Daniel</creator><creator>López-Fernández, Daniel</creator><creator>Aguiar-Santana, Ione A</creator><creator>Ayub, Adil</creator><creator>Alshehri, Khalid</creator><creator>Jordi, Nagib A</creator><creator>Zubeldia, José</creator><creator>Bröering, Dieter C</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20191001</creationdate><title>Pulsed Ultrasounds Reduce Pain and Disability, Increasing Rib Fracture Healing, in a Randomized Controlled Trial</title><author>Santana-Rodríguez, Norberto ; Clavo, Bernardino ; Llontop, Pedro ; Fiuza, María D ; Calatayud-Gastardi, Joaquín ; López, Daniel ; López-Fernández, Daniel ; Aguiar-Santana, Ione A ; Ayub, Adil ; Alshehri, Khalid ; Jordi, Nagib A ; Zubeldia, José ; Bröering, Dieter C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-ca53faa9b91f8a2bfc349fa6172da959e2c2566245fdd18248f95a42b28a2b213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Analgesics</topic><topic>Analysis</topic><topic>Bone healing</topic><topic>Callus</topic><topic>Care and treatment</topic><topic>Convalescence</topic><topic>Exercise</topic><topic>Fractures</topic><topic>Health aspects</topic><topic>Morbidity</topic><topic>Pain</topic><topic>Physical activity</topic><topic>Rib</topic><topic>Rib cage</topic><topic>Ultrasonic imaging</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santana-Rodríguez, Norberto</creatorcontrib><creatorcontrib>Clavo, Bernardino</creatorcontrib><creatorcontrib>Llontop, Pedro</creatorcontrib><creatorcontrib>Fiuza, María D</creatorcontrib><creatorcontrib>Calatayud-Gastardi, Joaquín</creatorcontrib><creatorcontrib>López, Daniel</creatorcontrib><creatorcontrib>López-Fernández, Daniel</creatorcontrib><creatorcontrib>Aguiar-Santana, Ione A</creatorcontrib><creatorcontrib>Ayub, Adil</creatorcontrib><creatorcontrib>Alshehri, Khalid</creatorcontrib><creatorcontrib>Jordi, Nagib A</creatorcontrib><creatorcontrib>Zubeldia, José</creatorcontrib><creatorcontrib>Bröering, Dieter C</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Pain medicine (Malden, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santana-Rodríguez, Norberto</au><au>Clavo, Bernardino</au><au>Llontop, Pedro</au><au>Fiuza, María D</au><au>Calatayud-Gastardi, Joaquín</au><au>López, Daniel</au><au>López-Fernández, Daniel</au><au>Aguiar-Santana, Ione A</au><au>Ayub, Adil</au><au>Alshehri, Khalid</au><au>Jordi, Nagib A</au><au>Zubeldia, José</au><au>Bröering, Dieter C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulsed Ultrasounds Reduce Pain and Disability, Increasing Rib Fracture Healing, in a Randomized Controlled Trial</atitle><jtitle>Pain medicine (Malden, Mass.)</jtitle><addtitle>Pain Med</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>20</volume><issue>10</issue><spage>1980</spage><epage>1988</epage><pages>1980-1988</pages><issn>1526-2375</issn><eissn>1526-4637</eissn><abstract>Rib fractures are an important health issue worldwide, with significant, pain, morbidity, and disability for which only symptomatic treatment exists.
Based on our previous experimental model, the objective of the current study was to assess for the first time whether pulsed ultrasound (PUS) application could have beneficial effects on humans.
Prospective, double-blinded, randomized, controlled trial of 51 patients. Four were excluded, and 47 were randomized into the control group (N = 23) or PUS group (N = 24). The control group received a PUS procedure without emission, and the PUS group received 1 Mhz, 0.5 W/cm2 for 1 min/cm2. Pain level, bone callus healing rate, physical and work activity, pain medication intake, and adverse events were blindly evaluated at baseline and one, three, and six months.
There were no significant differences at baseline between groups. PUS treatment significantly decreased pain by month 1 (P = 0.004), month 3 (P = 0.005), and month 6 (P = 0.025), significantly accelerated callus healing by month 1 (P = 0.013) and month 3 (P < 0.001), accelerated return to physical activity by month 3 (P = 0.036) and work activity (P = 0.001) by month 1, and considerably reduced pain medication intake by month 1 (P = 0.057) and month 3 (P = 0.017). No related adverse events were found in the PUS group.
This study is the first evidence that PUS treatment is capable of improving rib fracture outcome, significantly accelerating bone callus healing, and decreasing pain, time off due to both physical activity and convalescence period, and pain medication intake. It is a safe, efficient, and low-cost therapy that may become a new treatment for patients with stable rib fractures.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>30496510</pmid><doi>10.1093/pm/pny224</doi><tpages>9</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Analgesics Analysis Bone healing Callus Care and treatment Convalescence Exercise Fractures Health aspects Morbidity Pain Physical activity Rib Rib cage Ultrasonic imaging Ultrasound |
| title | Pulsed Ultrasounds Reduce Pain and Disability, Increasing Rib Fracture Healing, in a Randomized Controlled Trial |
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