Study of Anti-Tuberculosis Activity Behaviour of Natural Kaurane and Trachylobane Diterpenes Compared with Structural Properties Obtained by Theoretical Calculations

A set of seven diterpenes, three kauranes and four trachylobanes, isolated from the African plant Psiadia punctulata were assayed against Mycobacterium tuberculosis and reached activity comparable with cycloserine, a second line drug used to treat tuberculosis (TB). Several structural properties of...

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Veröffentlicht in:	Natural product communications 2017-05, Vol.12 (5), p.763-769
Hauptverfasser:	Soares, Ana C. F., Cabral, Mirela M. W., Martins, Carlos H. G., Ferreira, Alexsandro E., Bergamo, Pedro A. S., Omosa, Leonida K., Midiwo, Jacob O., Parreira, Renato L. T., Heleno, Vladimir C. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents - chemistry Antitubercular Agents - pharmacology Asteraceae - chemistry Biological Products - chemistry Biological Products - pharmacology Computer Simulation Diterpenes - chemistry Diterpenes - pharmacology Models, Molecular Molecular Structure Mycobacterium tuberculosis - drug effects Structure-Activity Relationship
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