microRNA‐186 inhibition of PI3K–AKT pathway via SPP1 inhibits chondrocyte apoptosis in mice with osteoarthritis

Chondrocyte apoptosis has been implicated as a major pathological osteoarthritis (OA) change in humans and experimental animals. We evaluate the ability of miR‐186 on chondrocyte apoptosis and proliferation in OA and elucidate the underlying mechanism concerning the regulation of miR‐186 in OA. Gene...

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Veröffentlicht in:	Journal of cellular physiology 2019-05, Vol.234 (5), p.6042-6053
Hauptverfasser:	Lin, Zeng, Tian, Xin‐Yi, Huang, Xi‐Xi, He, Ling‐Li, Xu, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Apoptosis Arthritis Arthritis, Experimental - chemically induced Arthritis, Experimental - enzymology Arthritis, Experimental - genetics Arthritis, Experimental - pathology Biocompatibility Biomedical materials Caspase 3 - metabolism Caspase 9 - metabolism Cell cycle Cell Proliferation Cell survival chondrocyte Chondrocytes Chondrocytes - enzymology Chondrocytes - pathology Databases, Genetic DNA microarrays Down-Regulation Gene expression Humans Joints - enzymology Joints - pathology Male Mice MicroRNAs - genetics MicroRNAs - metabolism microRNA‐186 miRNA NIH 3T3 Cells Osteoarthritis Osteoarthritis - chemically induced Osteoarthritis - enzymology Osteoarthritis - genetics Osteoarthritis - pathology Osteopontin - genetics Osteopontin - metabolism Papain Phosphatidylinositol 3-Kinase - genetics Phosphatidylinositol 3-Kinase - metabolism PI3K–AKT pathway proliferation Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Regulatory mechanisms (biology) Ribonucleic acid RNA RNA Interference Signal Transduction siRNA SPP1
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