Recombinant Antibody Production in CHO and NS0 Cells: Differences and Similarities

The commercial production of monoclonal antibodies (mAbs) has revolutionized the treatment of many diseases, including cancer, multiple sclerosis, and rheumatoid arthritis. These biotherapeutics have the potential to generate a global annual revenue of more than US$150 billion. Two cell hosts are pr...

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Veröffentlicht in:	BioDrugs : clinical immunotherapeutics, biopharmaceuticals, and gene therapy biopharmaceuticals, and gene therapy, 2018-12, Vol.32 (6), p.571-584
Hauptverfasser:	Dhara, Venkata Gayatri, Naik, Harnish Mukesh, Majewska, Natalia I., Betenbaugh, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Monoclonal - isolation & purification Batch processes Biomedical and Life Sciences Biomedicine Biotechnology industry Cancer Cancer Research Cell culture Cell Culture Techniques - methods Cell Line, Tumor CHO Cells - metabolism Cholesterol Cholesterol - metabolism Cricetulus Culture media Culture Media - chemistry Culture Media - metabolism Dihydrofolate reductase Gene expression Glutamate-ammonia ligase Glutamate-Ammonia Ligase - metabolism Glutamine Immunoglobulins Manufacturing Metabolism Metabolites Mice Molecular Medicine Monoclonal antibodies Multiple myeloma Multiple sclerosis Myeloma Pharmacotherapy Productivity Recombinant Proteins - isolation & purification Review Article Rheumatoid arthritis Tetrahydrofolate Dehydrogenase - metabolism
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