Effects of PVC bags sterilization process on the 5-fluorouracil stability

The stability and compatibility of 5-fluorouracil (5-FU) in undiluted or diluted admixtures stored in β-radiation sterilized portable poly(vinyl chloride) (PVC) infusion bags were investigated. Admixtures containing 5-FU 50 mg ml -1 not diluted or 25 mg ml -1 diluted in 0.9% sodium chloride injectio...

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Veröffentlicht in:	Biomaterials 1999-04, Vol.20 (7), p.655-661
Hauptverfasser:	Dine, T., Kahlfi, F., Duban, M., Gressier, B., Luyckx, M., Brunet, C., Meersseman, X., Goudaliez, F., Cazin, M., Cazin, J.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-FU Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - chemistry Beta Particles Biocompatibility Biocompatible Materials Biological and medical sciences Chemistry, Pharmaceutical Chromatography, High Pressure Liquid Diethylhexyl Phthalate - chemistry Drug Stability Drug therapy Fluorouracil - administration & dosage Fluorouracil - chemistry High performance liquid chromatography HPLC Hydrogen-Ion Concentration Infusions, Intravenous Medical sciences pH effects Plasticizers - chemistry Polyvinyl Chloride Polyvinyl chlorides Precipitation (chemical) PVC bag Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Sodium chloride Solutions Stability Sterilization (cleaning) Sterilization - methods Sterilization process Technology. Biomaterials. Equipments. Material. Instrumentation
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