Nickel Catalyzed syn-Selective Aryl Nickelation and Cyclization of Aldehyde/Enone-Tethered Terminal Alkynes with Arylboronic Acids

A syn-arylative nickelation followed by nucleophilic syn-selective cyclization of o-propargyloxy benzaldehydes is achieved toward the synthesis of chromanol skeletons with alkenyl substitution at C3. The capture of the intermediate vinyl nickel in its cis geometry is done also with a Michael accepto...

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Veröffentlicht in:	Journal of organic chemistry 2018-12, Vol.83 (24), p.15361-15371
Hauptverfasser:	Rajesh, Manda, Singam, Maneesh Kumar Reddy, Puri, Surendra, Balasubramanian, Sridhar, Sridhar Reddy, Maddi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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