Longitudinal assessment of cerebral perfusion and vascular response to hypoventilation in a bigenic mouse model of Alzheimer's disease with amyloid and tau pathology

Alzheimer's disease is the most common neurodegenerative disease, and many patients also present with vascular dysfunction. In this study, we aimed to assess cerebral blood flow (CBF) and cerebrovascular response (CVR) as early, pre‐symptomatic (3 months of age), imaging markers in a bigenic mo...

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Veröffentlicht in:	NMR in biomedicine 2019-02, Vol.32 (2), p.e4037-n/a
Hauptverfasser:	Govaerts, Kristof, Lechat, Benoit, Struys, Tom, Kremer, Anna, Borghgraef, Peter, Van Leuven, Fred, Himmelreich, Uwe, Dresselaers, Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - complications Alzheimer's disease Amyloid Amyloid beta-Protein Precursor - metabolism amyloid plaques Anesthesia Animal models Animals arterial spin labeling Biological products Blood flow Brain Brain - blood supply Carbon Dioxide - metabolism Cerebral blood flow cerebral perfusion Cerebrovascular system Cortex Disease Models, Animal Genotypes Hypoventilation Hypoventilation - complications Hypoventilation - physiopathology Isoflurane Isoflurane - administration & dosage Isoflurane - pharmacology Ketamine Magnetic resonance imaging Male Mechanical ventilation Mice Mice, Transgenic Midazolam Neurodegenerative diseases Neuroimaging Perfusion Plaque, Amyloid - pathology Spin labeling Tau protein tau Proteins - metabolism tau tangles Vasodilation Ventilation Ventilators Weaning
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