Rapid method for simultaneous determination of ascorbic acid and zinc in effervescent tablets by capillary zone electrophoresis with contactless conductivity detection
Ascorbic acid and zinc are essential nutrients that play important roles in nutrition, immune support, and maintenance of health. For this reason, both compounds are widely used as ingredients in dietary supplements. We report, for the first time, an analytical method for fast simultaneous determina...
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| Veröffentlicht in: | Journal of separation science 2019-02, Vol.42 (3), p.754-759 |
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| container_title | Journal of separation science |
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| creator | Ribeiro, Michelle Miranda A. C. Prado, Aliceana A. Domingues Batista, Alex Alejandro Abarza Munoz, Rodrigo Mathias Richter, Eduardo |
| description | Ascorbic acid and zinc are essential nutrients that play important roles in nutrition, immune support, and maintenance of health. For this reason, both compounds are widely used as ingredients in dietary supplements. We report, for the first time, an analytical method for fast simultaneous determination of ascorbic acid and zinc. A single analysis run is possible every 80 s (45 injections/h). The method is based on capillary electrophoresis with capacitively coupled contactless conductivity detection using a fused silica capillary with 50 cm length (effective length of 10 cm). The separation was achieved by using a background electrolyte composed by 30 mmol/L of 2‐(morpholin‐4‐yl)ethane‐1‐sulfonic acid and 30 mmol/L of histidine, pH 6.1. The detection limits were 10 and 20 μmol/L and recovery values for spiked samples were 101 and 100% for zinc and ascorbic acid, respectively. The results obtained with the developed procedure were compared to those obtained by titration (ascorbic acid) and flame atomic absorption spectroscopy (zinc), and no statistically significant differences were observed (95% confidence level). |
| doi_str_mv | 10.1002/jssc.201801042 |
| format | Article |
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C. ; Prado, Aliceana A. ; Domingues Batista, Alex ; Alejandro Abarza Munoz, Rodrigo ; Mathias Richter, Eduardo</creator><creatorcontrib>Ribeiro, Michelle Miranda A. C. ; Prado, Aliceana A. ; Domingues Batista, Alex ; Alejandro Abarza Munoz, Rodrigo ; Mathias Richter, Eduardo</creatorcontrib><description>Ascorbic acid and zinc are essential nutrients that play important roles in nutrition, immune support, and maintenance of health. For this reason, both compounds are widely used as ingredients in dietary supplements. We report, for the first time, an analytical method for fast simultaneous determination of ascorbic acid and zinc. A single analysis run is possible every 80 s (45 injections/h). The method is based on capillary electrophoresis with capacitively coupled contactless conductivity detection using a fused silica capillary with 50 cm length (effective length of 10 cm). The separation was achieved by using a background electrolyte composed by 30 mmol/L of 2‐(morpholin‐4‐yl)ethane‐1‐sulfonic acid and 30 mmol/L of histidine, pH 6.1. The detection limits were 10 and 20 μmol/L and recovery values for spiked samples were 101 and 100% for zinc and ascorbic acid, respectively. The results obtained with the developed procedure were compared to those obtained by titration (ascorbic acid) and flame atomic absorption spectroscopy (zinc), and no statistically significant differences were observed (95% confidence level).</description><identifier>ISSN: 1615-9306</identifier><identifier>EISSN: 1615-9314</identifier><identifier>DOI: 10.1002/jssc.201801042</identifier><identifier>PMID: 30488578</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Acids ; Ascorbic acid ; Atomic absorption analysis ; Atomic beam spectroscopy ; Confidence intervals ; Electrophoresis ; Ethane ; fast analysis ; Fused silica ; Histidine ; Nutrients ; Nutrition ; organic compounds ; Silicon dioxide ; simultaneous analysis ; Statistical analysis ; Statistical methods ; Sulfonic acid ; Tablets ; Titration ; transition metals ; Vitamin C ; vitamins ; Zinc</subject><ispartof>Journal of separation science, 2019-02, Vol.42 (3), p.754-759</ispartof><rights>2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3689-f2e5e982eebeec57ebf5abdb878ece1ae15111da66c219dee8dfb2d42dbd48b03</citedby><cites>FETCH-LOGICAL-c3689-f2e5e982eebeec57ebf5abdb878ece1ae15111da66c219dee8dfb2d42dbd48b03</cites><orcidid>0000-0002-3840-8277</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjssc.201801042$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjssc.201801042$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30488578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ribeiro, Michelle Miranda A. C.</creatorcontrib><creatorcontrib>Prado, Aliceana A.</creatorcontrib><creatorcontrib>Domingues Batista, Alex</creatorcontrib><creatorcontrib>Alejandro Abarza Munoz, Rodrigo</creatorcontrib><creatorcontrib>Mathias Richter, Eduardo</creatorcontrib><title>Rapid method for simultaneous determination of ascorbic acid and zinc in effervescent tablets by capillary zone electrophoresis with contactless conductivity detection</title><title>Journal of separation science</title><addtitle>J Sep Sci</addtitle><description>Ascorbic acid and zinc are essential nutrients that play important roles in nutrition, immune support, and maintenance of health. For this reason, both compounds are widely used as ingredients in dietary supplements. We report, for the first time, an analytical method for fast simultaneous determination of ascorbic acid and zinc. A single analysis run is possible every 80 s (45 injections/h). The method is based on capillary electrophoresis with capacitively coupled contactless conductivity detection using a fused silica capillary with 50 cm length (effective length of 10 cm). The separation was achieved by using a background electrolyte composed by 30 mmol/L of 2‐(morpholin‐4‐yl)ethane‐1‐sulfonic acid and 30 mmol/L of histidine, pH 6.1. The detection limits were 10 and 20 μmol/L and recovery values for spiked samples were 101 and 100% for zinc and ascorbic acid, respectively. The results obtained with the developed procedure were compared to those obtained by titration (ascorbic acid) and flame atomic absorption spectroscopy (zinc), and no statistically significant differences were observed (95% confidence level).</description><subject>Acids</subject><subject>Ascorbic acid</subject><subject>Atomic absorption analysis</subject><subject>Atomic beam spectroscopy</subject><subject>Confidence intervals</subject><subject>Electrophoresis</subject><subject>Ethane</subject><subject>fast analysis</subject><subject>Fused silica</subject><subject>Histidine</subject><subject>Nutrients</subject><subject>Nutrition</subject><subject>organic compounds</subject><subject>Silicon dioxide</subject><subject>simultaneous analysis</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Sulfonic acid</subject><subject>Tablets</subject><subject>Titration</subject><subject>transition metals</subject><subject>Vitamin C</subject><subject>vitamins</subject><subject>Zinc</subject><issn>1615-9306</issn><issn>1615-9314</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkT1PHDEQhq0IFAhJS4ks0dDcxfbuer0lOkEShBSJj3rlj7HOp137sL2g4w_lb-LjyBVpUs0Uz7zvzLwInVIyp4Sw76uU9JwRKgglNfuEjimnzayraH2w7wk_Ql9SWhFCW9GRz-ioIrUQTSuO0Z87uXYGj5CXwWAbIk5unIYsPYQpYQMZ4ui8zC54HCyWSYeonMZSlzHpDX51XmPnMVgL8RmSBp9xlmqAnLDaYF0MhkHGDX4NHjAMoHMM62WIkFzCLy4vsQ4-S50HSGnbm0ln9-zy5t1fb72_okMrhwTfPuoJery-elj8nN3-_vFrcXk70xUX3cwyaKATDEAB6KYFZRupjBKtAA1UAm0opUZyrhntDIAwVjFTM6NMLRSpTtDFTncdw9MEKfejKyeVA94f0jNadQ3nVdsU9PwfdBWm6Mt2hWpr1nYt5YWa7ygdQ0oRbL-Obizv6CnptxH22wj7fYRl4OxDdlIjmD3-N7MC1DvgxQ2w-Y9cf3N_v-Bll-oNhk2uFQ</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Ribeiro, Michelle Miranda A. 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C. ; Prado, Aliceana A. ; Domingues Batista, Alex ; Alejandro Abarza Munoz, Rodrigo ; Mathias Richter, Eduardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3689-f2e5e982eebeec57ebf5abdb878ece1ae15111da66c219dee8dfb2d42dbd48b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acids</topic><topic>Ascorbic acid</topic><topic>Atomic absorption analysis</topic><topic>Atomic beam spectroscopy</topic><topic>Confidence intervals</topic><topic>Electrophoresis</topic><topic>Ethane</topic><topic>fast analysis</topic><topic>Fused silica</topic><topic>Histidine</topic><topic>Nutrients</topic><topic>Nutrition</topic><topic>organic compounds</topic><topic>Silicon dioxide</topic><topic>simultaneous analysis</topic><topic>Statistical analysis</topic><topic>Statistical methods</topic><topic>Sulfonic acid</topic><topic>Tablets</topic><topic>Titration</topic><topic>transition metals</topic><topic>Vitamin C</topic><topic>vitamins</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ribeiro, Michelle Miranda A. C.</creatorcontrib><creatorcontrib>Prado, Aliceana A.</creatorcontrib><creatorcontrib>Domingues Batista, Alex</creatorcontrib><creatorcontrib>Alejandro Abarza Munoz, Rodrigo</creatorcontrib><creatorcontrib>Mathias Richter, Eduardo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of separation science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ribeiro, Michelle Miranda A. 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A single analysis run is possible every 80 s (45 injections/h). The method is based on capillary electrophoresis with capacitively coupled contactless conductivity detection using a fused silica capillary with 50 cm length (effective length of 10 cm). The separation was achieved by using a background electrolyte composed by 30 mmol/L of 2‐(morpholin‐4‐yl)ethane‐1‐sulfonic acid and 30 mmol/L of histidine, pH 6.1. The detection limits were 10 and 20 μmol/L and recovery values for spiked samples were 101 and 100% for zinc and ascorbic acid, respectively. The results obtained with the developed procedure were compared to those obtained by titration (ascorbic acid) and flame atomic absorption spectroscopy (zinc), and no statistically significant differences were observed (95% confidence level).</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30488578</pmid><doi>10.1002/jssc.201801042</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-3840-8277</orcidid></addata></record> |
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| subjects | Acids Ascorbic acid Atomic absorption analysis Atomic beam spectroscopy Confidence intervals Electrophoresis Ethane fast analysis Fused silica Histidine Nutrients Nutrition organic compounds Silicon dioxide simultaneous analysis Statistical analysis Statistical methods Sulfonic acid Tablets Titration transition metals Vitamin C vitamins Zinc |
| title | Rapid method for simultaneous determination of ascorbic acid and zinc in effervescent tablets by capillary zone electrophoresis with contactless conductivity detection |
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