Kinetics of Lipase Catalyzed Enantioselective Esterification of Racemic Ibuprofen in Isooctane
The kinetics of Candida rugosa lipase catalyzed esteritlcation of racemic ibuprofen with n-butanol in isooctane was studied. The kinetic study was carried out with the addition of 0.1% and 2% (by volume) of water for enzyme activation respectively when celite was added into isooctane for enzyme disp...
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| Veröffentlicht in: | Chinese journal of chemical engineering 2000-03, Vol.8 (1), p.6-14 |
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| creator | 谢渝春 刘会洲 陈家镛 |
| description | The kinetics of Candida rugosa lipase catalyzed esteritlcation of racemic ibuprofen with n-butanol in isooctane was studied. The kinetic study was carried out with the addition of 0.1% and 2% (by volume) of water for enzyme activation respectively when celite was added into isooctane for enzyme dispersion. The specific initial rate for S-ibuprofen can be fitted with the Ping Pong Bi Bi mechanism with dead-end competitive inhibition by the alcohol. The time courses of the enantioselective esteriflcation of the two ibuprofen enantiomers with different initial substrate concentrations and water contents were simulated with a model in which both effects of enzyme inactivation by long term reaction and reversed hydrolytic reaction under high water content were taken into consideration. |
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The kinetic study was carried out with the addition of 0.1% and 2% (by volume) of water for enzyme activation respectively when celite was added into isooctane for enzyme dispersion. The specific initial rate for S-ibuprofen can be fitted with the Ping Pong Bi Bi mechanism with dead-end competitive inhibition by the alcohol. The time courses of the enantioselective esteriflcation of the two ibuprofen enantiomers with different initial substrate concentrations and water contents were simulated with a model in which both effects of enzyme inactivation by long term reaction and reversed hydrolytic reaction under high water content were taken into consideration.</description><identifier>ISSN: 1004-9541</identifier><identifier>EISSN: 2210-321X</identifier><language>eng</language><subject>Catalysts ; Dispersions ; Enzyme kinetics ; Enzymes ; Esterification ; Organic solvents ; Paraffins ; Water ; 动力学 ; 外消旋 ; 对映选择性 ; 异丁苯酸 ; 异辛烷 ; 消炎药 ; 脂肪酶 ; 酯化作用</subject><ispartof>Chinese journal of chemical engineering, 2000-03, Vol.8 (1), p.6-14</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84275X/84275X.jpg</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>谢渝春 刘会洲 陈家镛</creatorcontrib><title>Kinetics of Lipase Catalyzed Enantioselective Esterification of Racemic Ibuprofen in Isooctane</title><title>Chinese journal of chemical engineering</title><addtitle>Chinese Journal of Chemical Engineering</addtitle><description>The kinetics of Candida rugosa lipase catalyzed esteritlcation of racemic ibuprofen with n-butanol in isooctane was studied. 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The time courses of the enantioselective esteriflcation of the two ibuprofen enantiomers with different initial substrate concentrations and water contents were simulated with a model in which both effects of enzyme inactivation by long term reaction and reversed hydrolytic reaction under high water content were taken into consideration.</description><subject>Catalysts</subject><subject>Dispersions</subject><subject>Enzyme kinetics</subject><subject>Enzymes</subject><subject>Esterification</subject><subject>Organic solvents</subject><subject>Paraffins</subject><subject>Water</subject><subject>动力学</subject><subject>外消旋</subject><subject>对映选择性</subject><subject>异丁苯酸</subject><subject>异辛烷</subject><subject>消炎药</subject><subject>脂肪酶</subject><subject>酯化作用</subject><issn>1004-9541</issn><issn>2210-321X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNotjk1LAzEYhIMoWKv_IV68LeRzNzlKqVpaEETBk0vy7psa3WbbJhX017tS5zIwzAzPCZkIwVklBX89JRPOmKqsVvycXOT8wZhghpsJeVvGhCVCpkOgq7h1GenMFdd__2BH58mlEoeMPUKJX0jnueA-hghujNPf5skBbiLQhT9s90PARGOiizwMUFzCS3IWXJ_x6t-n5OVu_jx7qFaP94vZ7aqCkbFUqvNeagVCdmh0I5ugLHQqWKhFUKFWzDOrR3FjlOq089hYwRgwj1oHJ6fk5vg7MuwOmEu7iRmw70eG4ZBbwaUVDTdj8fpYhPchrXcxrVvv4DPEHltTq7oWVv4C_KdeIA</recordid><startdate>20000301</startdate><enddate>20000301</enddate><creator>谢渝春 刘会洲 陈家镛</creator><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W92</scope><scope>~WA</scope></search><sort><creationdate>20000301</creationdate><title>Kinetics of Lipase Catalyzed Enantioselective Esterification of Racemic Ibuprofen in Isooctane</title><author>谢渝春 刘会洲 陈家镛</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c210t-4dbb354c23de85737f49cd4f9c62f4f640b09555518844d5abe79200c0be55fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Catalysts</topic><topic>Dispersions</topic><topic>Enzyme kinetics</topic><topic>Enzymes</topic><topic>Esterification</topic><topic>Organic solvents</topic><topic>Paraffins</topic><topic>Water</topic><topic>动力学</topic><topic>外消旋</topic><topic>对映选择性</topic><topic>异丁苯酸</topic><topic>异辛烷</topic><topic>消炎药</topic><topic>脂肪酶</topic><topic>酯化作用</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>谢渝春 刘会洲 陈家镛</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-工程技术</collection><collection>中文科技期刊数据库- 镜像站点</collection><jtitle>Chinese journal of chemical engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>谢渝春 刘会洲 陈家镛</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kinetics of Lipase Catalyzed Enantioselective Esterification of Racemic Ibuprofen in Isooctane</atitle><jtitle>Chinese journal of chemical engineering</jtitle><addtitle>Chinese Journal of Chemical Engineering</addtitle><date>2000-03-01</date><risdate>2000</risdate><volume>8</volume><issue>1</issue><spage>6</spage><epage>14</epage><pages>6-14</pages><issn>1004-9541</issn><eissn>2210-321X</eissn><abstract>The kinetics of Candida rugosa lipase catalyzed esteritlcation of racemic ibuprofen with n-butanol in isooctane was studied. The kinetic study was carried out with the addition of 0.1% and 2% (by volume) of water for enzyme activation respectively when celite was added into isooctane for enzyme dispersion. The specific initial rate for S-ibuprofen can be fitted with the Ping Pong Bi Bi mechanism with dead-end competitive inhibition by the alcohol. The time courses of the enantioselective esteriflcation of the two ibuprofen enantiomers with different initial substrate concentrations and water contents were simulated with a model in which both effects of enzyme inactivation by long term reaction and reversed hydrolytic reaction under high water content were taken into consideration.</abstract><tpages>9</tpages></addata></record> |
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| ispartof | Chinese journal of chemical engineering, 2000-03, Vol.8 (1), p.6-14 |
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| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Catalysts Dispersions Enzyme kinetics Enzymes Esterification Organic solvents Paraffins Water 动力学 外消旋 对映选择性 异丁苯酸 异辛烷 消炎药 脂肪酶 酯化作用 |
| title | Kinetics of Lipase Catalyzed Enantioselective Esterification of Racemic Ibuprofen in Isooctane |
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