Determinants for Differential Effects on d-Ala-d-Lactate vs d-Ala-d-Ala Formation by the VanA Ligase from Vancomycin-Resistant Enterococci

Bacteria with either intrinsic or inducible resistance to vancomycin make peptidoglycan (PG) precursors of lowered affinity for the antibiotic by switching the PG-d-Ala-d-Ala termini that are the antibiotic-binding target to either PG-d-Ala-d-lactate or PG-d-Ala-d-Ser as a consequence of altered spe...

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Veröffentlicht in:	Biochemistry (Easton) 1999-10, Vol.38 (42), p.14006-14022
Hauptverfasser:	Lessard, Ivan A. D, Healy, Vicki L, Park, Il-Seon, Walsh, Christopher T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Alanine - analogs & derivatives Alanine - chemistry Alanine - metabolism Amino Acid Sequence Anti-Bacterial Agents - metabolism Antibiotics Arginine - genetics Bacteria Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Base Sequence Biosynthesis Carbon-Oxygen Ligases - chemistry Carbon-Oxygen Ligases - genetics Carbon-Oxygen Ligases - metabolism Catalysis Catalyst selectivity Cells Chemical activation Chemical bonds Dipeptides - metabolism Enterococcus Enterococcus - enzymology Enterococcus - genetics Enzyme Activation - genetics Histidine - genetics Hydrogen-Ion Concentration Lactic Acid - chemistry Lactic Acid - metabolism Leuconostoc - enzymology Ligands ligase Lysine - genetics Molecular Sequence Data Mutagenesis Mutagenesis, Site-Directed Peptide Synthases - chemistry Peptide Synthases - genetics Peptide Synthases - metabolism Stereoisomerism Templates, Genetic VanA protein Vancomycin - chemistry Vancomycin Resistance
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