Structure–function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans

Little is known about the specificities and neutralization breadth of the H7-reactive antibody repertoire induced by natural H7N9 infection in humans. We have isolated and characterized 73 H7-reactive monoclonal antibodies from peripheral B cells from four donors infected in 2013 and 2014. Of these,...

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Veröffentlicht in:	Nature microbiology 2019-02, Vol.4 (2), p.306-315
Hauptverfasser:	Huang, Kuan-Ying A., Rijal, Pramila, Jiang, Haihai, Wang, Beibei, Schimanski, Lisa, Dong, Tao, Liu, Yo-Min, Chang, Pengxiang, Iqbal, Munir, Wang, Mu-Chun, Chen, Zhihai, Song, Rui, Huang, Chung-Chi, Yang, Jeng-How, Qi, Jianxun, Lin, Tzou-Yien, Li, Ang, Powell, Timothy J., Jan, Jia-Tsrong, Ma, Che, Gao, George F., Shi, Yi, Townsend, Alain R.
Format:	Artikel
Sprache:	eng
Schlagworte:	101/1 13/1 631/250 631/326 631/535 Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Antibodies, Neutralizing - administration & dosage Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - immunology Antibodies, Neutralizing - metabolism Antibodies, Viral - administration & dosage Antibodies, Viral - chemistry Antibodies, Viral - immunology Antibodies, Viral - metabolism Binding Sites Biomedical and Life Sciences Cross Reactions - immunology Disease Models, Animal Epitopes Female Hemagglutinin Glycoproteins, Influenza Virus - chemistry Hemagglutinin Glycoproteins, Influenza Virus - immunology Hemagglutinin Glycoproteins, Influenza Virus - metabolism Hemagglutinins Humans Immunoglobulins Infectious Diseases Influenza Influenza A Virus, H7N9 Subtype - immunology Influenza, Human - immunology Influenza, Human - prevention & control Life Sciences Lymphocytes B Medical Microbiology Mice, Inbred BALB C Microbiology Monoclonal antibodies Mutation Parasitology Protein Conformation Rivers Structure-function relationships Virology
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