Investigation of morphological, mechanical and biological properties of cellulose nanocrystal reinforced electrospun gelatin nanofibers

Investigation of morphological, mechanical and biological properties of cellulose nanocrystal reinforced electrospun gelatin nanofibers

Incorporation of nanoparticles into biomaterials is of interest due to the high demand for medical devices with enhanced mechanical properties. In this study, cellulose nanocrystals (CNC) were incorporated in electrospun gelatin nanofibers at various loadings (0–15% w/w) and characterized using XRD,...

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Veröffentlicht in:International journal of biological macromolecules 2019-03, Vol.124, p.411-417
Hauptverfasser: Hivechi, Ahmad, Hajir Bahrami, S., Siegel, Ronald A.
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Biological properties
Cellulose nanocrystals
Gelatin nanofibers
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container_title International journal of biological macromolecules
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creator Hivechi, Ahmad
Hajir Bahrami, S.
Siegel, Ronald A.
description Incorporation of nanoparticles into biomaterials is of interest due to the high demand for medical devices with enhanced mechanical properties. In this study, cellulose nanocrystals (CNC) were incorporated in electrospun gelatin nanofibers at various loadings (0–15% w/w) and characterized using XRD, TGA, TEM, SEM, FTIR, and tensile tests. Results obtained from TGA and tensile properties indicate that CNC were agglomerated at loadings exceeding 5%; however, TEM showed excellent dispersion of nanoparticles at 5% CNC. A slight increase in biodegradability of crosslinked gelatin nanofibers was observed with CNC incorporation. MTT cytotoxicity, fluorescent staining, and SEM images showed that CNC had no significant effect on cell growth and proliferation. [Display omitted]
doi_str_mv 10.1016/j.ijbiomac.2018.11.214
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subjects Biological properties
Cellulose nanocrystals
Gelatin nanofibers
title Investigation of morphological, mechanical and biological properties of cellulose nanocrystal reinforced electrospun gelatin nanofibers
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