Prostasin Impairs Epithelial Growth Factor Receptor Activation to Suppress Dengue Virus Propagation

Abstract Background Dengue virus (DENV), a common and widely spread arbovirus, causes life-threatening diseases, such as dengue hemorrhagic fever or dengue shock syndrome. There is currently no effective therapeutic or preventive treatment for DENV infection. Methods Next-generation sequencing analy...

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Veröffentlicht in:	The Journal of infectious diseases 2019-04, Vol.219 (9), p.1377-1388
Hauptverfasser:	Lin, Chun-Kuang, Tseng, Chin-Kai, Wu, Yu-Hsuan, Lin, Chun-Yu, Huang, Chung-Hao, Wang, Weng-Hung, Liaw, Chih-Chuang, Chen, Yen-Hsu, Lee, Jin-Ching
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animals Cell Line Chromones - pharmacology Copy number Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Dengue - blood Dengue fever Dengue hemorrhagic fever Dengue Virus - genetics Dengue Virus - physiology Disease Models, Animal Enzyme Inhibitors - pharmacology Epidermal growth factor receptors ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics ErbB Receptors - metabolism Fibroblast growth factor 2 Growth factors Humans Infections Inositol Mice Monocytes - metabolism Morpholines - pharmacology Next-generation sequencing NF-κB protein Patients Polymerase chain reaction Receptor mechanisms Ribonucleic acid RNA RNA, Messenger - metabolism RNA, Small Interfering - pharmacology RNA, Viral Sequence analysis Serine Endopeptidases - blood Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Signal Transduction Suckling behavior Transfection Virus Replication - genetics
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