Use of a Single CAR T Cell and Several Bispecific Adapters Facilitates Eradication of Multiple Antigenically Different Solid Tumors

: Most solid tumors are comprised of multiple clones that express orthogonal antigens, suggesting that novel strategies must be developed in order to adapt chimeric antigen receptor (CAR) T-cell therapies to treat heterogeneous solid tumors. Here, we utilized a cocktail of low-molecular-weight bispe...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2019-01, Vol.79 (2), p.387-396
Hauptverfasser:	Lee, Yong Gu, Marks, Isaac, Srinivasarao, Madduri, Kanduluru, Ananda Kumar, Mahalingam, Sakkarapalayam M, Liu, Xin, Chu, Haiyan, Low, Philip S
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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