Design, synthesis and cytotoxicity of chimeric erlotinib-alkylphospholipid hybrids

[Display omitted] •Evaluation against cell lines eliciting low response to erlotinib and miltefosine.•Amide analogs were active than ester analogs.•Most of the amide analogs were superior to erlotinib and miltefosine.•EGFR and Akt phorphorylation inhibition were not correlated to cells growth inhibi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic chemistry 2019-03, Vol.84, p.51-62
Hauptverfasser:	Alam, Md. Maqusood, Hassan, Ahmed H.E., Lee, Kun Won, Cho, Min Chang, Yang, Ji Seul, Song, Jiho, Min, Kyung Hoon, Hong, Jongki, Kim, Dong-Hyun, Lee, Yong Sup
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt phosphorylation Alkylphospholipids (APL) Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Design Drug Screening Assays, Antitumor Epidermal growth factor receptor (EGFR) ErbB Receptors - antagonists & inhibitors ErbB Receptors - metabolism Erlotinib Erlotinib Hydrochloride - chemistry Erlotinib Hydrochloride - pharmacology Humans Molecular Structure Phospholipids - chemistry Phospholipids - pharmacology Phosphorylation - drug effects Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!