Selective suppression of excipient signals in 2D 1H–13C methyl spectra of biopharmaceutical products

While the use of 1 H– 13 C methyl correlated NMR spectroscopy at natural isotopic abundance has been demonstrated as feasible on protein therapeutics as large as monoclonal antibodies, spectral interference from aliphatic excipients remains a significant obstacle to its widespread application. These...

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