Brain grey matter volume reduction and anxiety-like behavior in lipopolysaccharide-induced chronic pulmonary inflammation rats: A structural MRI study with histological validation

•Chronic pulmonary inflammation results in decreased brain grey matter volume (GMV).•Elevated circulating inflammatory markers (IMs) correlate to brain GMV reduction.•The various IMs present differential neuroanatomical correlation patterns.•Lower GMVs in IM-related brain regions are associated with...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2019-02, Vol.76, p.182-197
Hauptverfasser:	Chen, Ji, Yan, Ya, Yuan, Fengjuan, Cao, Jianbo, Li, Shanhua, Eickhoff, Simon B., Zhang, Jiaxing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety - metabolism Anxiety - physiopathology Brain - metabolism Brain MRI Chronic systemic inflammation Cytokines Gray Matter - anatomy & histology Gray Matter - pathology Histological validation Image Processing, Computer-Assisted Lipopolysaccharides - metabolism Lipopolysaccharides - pharmacology Magnetic Resonance Imaging - methods Magnetic Resonance Imaging - veterinary Male Pneumonia - physiopathology Rats Rats, Sprague-Dawley Voxel-based morphometry
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