Anti-inflammatory Effects of Compounds from Polygonum odoratum
Polygonum odoratum is an edible plant traditionally used as an antidiabetic, antimicrobial, anti-inflammatory, and antitumor agent in Asia. The aim of the study was to evaluate the anti-inflammatory effect of P. odoratum and the isolation and characterization of its main fractions. Extracts of the a...
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| Veröffentlicht in: | Natural product communications 2016-11, Vol.11 (11), p.1651-1654 |
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| creator | Okonogi, Siriporn Kheawfu, Kantaporn Holzer, Wolfgang Unger, Frank M. Viernstein, Helmut Mueller, Monika |
| description | Polygonum odoratum is an edible plant traditionally used as an antidiabetic, antimicrobial, anti-inflammatory, and antitumor agent in Asia. The aim of the study was to evaluate the anti-inflammatory effect of P. odoratum and the isolation and characterization of its main fractions. Extracts of the aerial parts were tested for anti-inflammatory activity as indicated by a change in the cytokine secretion in lipopolysaccharide-stimulated macrophages. After separation of the extract by reversed-phase high-performance liquid chromatography, the anti-inflammatory activity of the fractions was determined. Furthermore, the two main fractions were identified by nuclear magnetic resonance spectroscopy (1H- and 13C-NMR). The ethanolic extract significantly reduced IL-6 secretion (IC50 25 μg/mL). The two main fractions (5 and 7) significantly decreased IL-6 production with an IC50 of 102 μM (5) and 77 μM (7), respectively, and were identified as scutellarein-7-glucoside (5) and quercitrin (7). Since inflammation plays a major role in various diseases with high prevalence globally, it may be of importance that P. odoratum and its main constituents scutellarein-7-glucoside and quercitrin can be used as either an alternative or complementary treatment. Additionally, both are glycosides and their activity may be enhanced tremendously by deglycosylation by the gut microbiota. |
| doi_str_mv | 10.1177/1934578X1601101107 |
| format | Article |
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The aim of the study was to evaluate the anti-inflammatory effect of P. odoratum and the isolation and characterization of its main fractions. Extracts of the aerial parts were tested for anti-inflammatory activity as indicated by a change in the cytokine secretion in lipopolysaccharide-stimulated macrophages. After separation of the extract by reversed-phase high-performance liquid chromatography, the anti-inflammatory activity of the fractions was determined. Furthermore, the two main fractions were identified by nuclear magnetic resonance spectroscopy (1H- and 13C-NMR). The ethanolic extract significantly reduced IL-6 secretion (IC50 25 μg/mL). The two main fractions (5 and 7) significantly decreased IL-6 production with an IC50 of 102 μM (5) and 77 μM (7), respectively, and were identified as scutellarein-7-glucoside (5) and quercitrin (7). Since inflammation plays a major role in various diseases with high prevalence globally, it may be of importance that P. odoratum and its main constituents scutellarein-7-glucoside and quercitrin can be used as either an alternative or complementary treatment. Additionally, both are glycosides and their activity may be enhanced tremendously by deglycosylation by the gut microbiota.</description><identifier>ISSN: 1934-578X</identifier><identifier>EISSN: 1555-9475</identifier><identifier>DOI: 10.1177/1934578X1601101107</identifier><identifier>PMID: 30475499</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Animals ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - pharmacology ; Gene Expression Regulation - drug effects ; Lipopolysaccharides - toxicity ; Macrophages - drug effects ; Macrophages - metabolism ; Mice ; Polygonum - chemistry ; RAW 264.7 Cells</subject><ispartof>Natural product communications, 2016-11, Vol.11 (11), p.1651-1654</ispartof><rights>2016 SAGE Publications Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-7936b538010b8247a816b7dd776e5fb4bdb44aa45010a5885434232e9c3ed50e3</citedby><cites>FETCH-LOGICAL-c502t-7936b538010b8247a816b7dd776e5fb4bdb44aa45010a5885434232e9c3ed50e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1934578X1601101107$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1934578X1601101107$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21945,27830,27901,27902,44921,45309</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/1934578X1601101107?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30475499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okonogi, Siriporn</creatorcontrib><creatorcontrib>Kheawfu, Kantaporn</creatorcontrib><creatorcontrib>Holzer, Wolfgang</creatorcontrib><creatorcontrib>Unger, Frank M.</creatorcontrib><creatorcontrib>Viernstein, Helmut</creatorcontrib><creatorcontrib>Mueller, Monika</creatorcontrib><title>Anti-inflammatory Effects of Compounds from Polygonum odoratum</title><title>Natural product communications</title><addtitle>Nat Prod Commun</addtitle><description>Polygonum odoratum is an edible plant traditionally used as an antidiabetic, antimicrobial, anti-inflammatory, and antitumor agent in Asia. The aim of the study was to evaluate the anti-inflammatory effect of P. odoratum and the isolation and characterization of its main fractions. Extracts of the aerial parts were tested for anti-inflammatory activity as indicated by a change in the cytokine secretion in lipopolysaccharide-stimulated macrophages. After separation of the extract by reversed-phase high-performance liquid chromatography, the anti-inflammatory activity of the fractions was determined. Furthermore, the two main fractions were identified by nuclear magnetic resonance spectroscopy (1H- and 13C-NMR). The ethanolic extract significantly reduced IL-6 secretion (IC50 25 μg/mL). The two main fractions (5 and 7) significantly decreased IL-6 production with an IC50 of 102 μM (5) and 77 μM (7), respectively, and were identified as scutellarein-7-glucoside (5) and quercitrin (7). Since inflammation plays a major role in various diseases with high prevalence globally, it may be of importance that P. odoratum and its main constituents scutellarein-7-glucoside and quercitrin can be used as either an alternative or complementary treatment. Additionally, both are glycosides and their activity may be enhanced tremendously by deglycosylation by the gut microbiota.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Lipopolysaccharides - toxicity</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - metabolism</subject><subject>Mice</subject><subject>Polygonum - chemistry</subject><subject>RAW 264.7 Cells</subject><issn>1934-578X</issn><issn>1555-9475</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotmj_gAfZo5e1ySbZJBehlPoBBT0oeAvJblK2bDY12Rz6701p9SI4DMwcnnlgXgBuELxHiLE5EphQxj9RDRE6NDsDU0QpLQVh9DzvGSgPxATMYtzCXJwTSMQlmGCYGSLEFDwshrEru8H2yjk1-rAvVtaaZoyFt8XSu51PQxsLG7wr3ny_3_ghucK3PqgxuWtwYVUfzew0r8DH4-p9-VyuX59elot12VBYjSUTuNYUc4ig5hVhiqNas7ZlrDbUaqJbTYhShGZAUc4pwaTClRENNi2FBl-Bu6N3F_xXMnGUrouN6Xs1GJ-irFCWU8hxndHqiDbBxxiMlbvQORX2EkF5iE7-jS4f3Z78STvT_p78BJWB-RGIamPk1qcw5H__U34DmVV1SA</recordid><startdate>201611</startdate><enddate>201611</enddate><creator>Okonogi, Siriporn</creator><creator>Kheawfu, Kantaporn</creator><creator>Holzer, Wolfgang</creator><creator>Unger, Frank M.</creator><creator>Viernstein, Helmut</creator><creator>Mueller, Monika</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201611</creationdate><title>Anti-inflammatory Effects of Compounds from Polygonum odoratum</title><author>Okonogi, Siriporn ; Kheawfu, Kantaporn ; Holzer, Wolfgang ; Unger, Frank M. ; Viernstein, Helmut ; Mueller, Monika</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-7936b538010b8247a816b7dd776e5fb4bdb44aa45010a5885434232e9c3ed50e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - chemistry</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Lipopolysaccharides - toxicity</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - metabolism</topic><topic>Mice</topic><topic>Polygonum - chemistry</topic><topic>RAW 264.7 Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okonogi, Siriporn</creatorcontrib><creatorcontrib>Kheawfu, Kantaporn</creatorcontrib><creatorcontrib>Holzer, Wolfgang</creatorcontrib><creatorcontrib>Unger, Frank M.</creatorcontrib><creatorcontrib>Viernstein, Helmut</creatorcontrib><creatorcontrib>Mueller, Monika</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Natural product communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Okonogi, Siriporn</au><au>Kheawfu, Kantaporn</au><au>Holzer, Wolfgang</au><au>Unger, Frank M.</au><au>Viernstein, Helmut</au><au>Mueller, Monika</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory Effects of Compounds from Polygonum odoratum</atitle><jtitle>Natural product communications</jtitle><addtitle>Nat Prod Commun</addtitle><date>2016-11</date><risdate>2016</risdate><volume>11</volume><issue>11</issue><spage>1651</spage><epage>1654</epage><pages>1651-1654</pages><issn>1934-578X</issn><eissn>1555-9475</eissn><abstract>Polygonum odoratum is an edible plant traditionally used as an antidiabetic, antimicrobial, anti-inflammatory, and antitumor agent in Asia. The aim of the study was to evaluate the anti-inflammatory effect of P. odoratum and the isolation and characterization of its main fractions. Extracts of the aerial parts were tested for anti-inflammatory activity as indicated by a change in the cytokine secretion in lipopolysaccharide-stimulated macrophages. After separation of the extract by reversed-phase high-performance liquid chromatography, the anti-inflammatory activity of the fractions was determined. Furthermore, the two main fractions were identified by nuclear magnetic resonance spectroscopy (1H- and 13C-NMR). The ethanolic extract significantly reduced IL-6 secretion (IC50 25 μg/mL). The two main fractions (5 and 7) significantly decreased IL-6 production with an IC50 of 102 μM (5) and 77 μM (7), respectively, and were identified as scutellarein-7-glucoside (5) and quercitrin (7). Since inflammation plays a major role in various diseases with high prevalence globally, it may be of importance that P. odoratum and its main constituents scutellarein-7-glucoside and quercitrin can be used as either an alternative or complementary treatment. Additionally, both are glycosides and their activity may be enhanced tremendously by deglycosylation by the gut microbiota.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>30475499</pmid><doi>10.1177/1934578X1601101107</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Gene Expression Regulation - drug effects Lipopolysaccharides - toxicity Macrophages - drug effects Macrophages - metabolism Mice Polygonum - chemistry RAW 264.7 Cells |
| title | Anti-inflammatory Effects of Compounds from Polygonum odoratum |
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