Ocular surface adverse events of systemic epidermal growth factor receptor inhibitors (EGFRi): A prospective trial

Controversy exists regarding the safety of agents that systemically inhibit epidermal growth factor receptor (EGFRi) in oncologic patients in terms of toxicity to the ocular surface. We performed a prospective clinical study comparing the ocular surface toxicity of systemic EGFRi between a case and...

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Veröffentlicht in:	Journal francais d'ophtalmologie 2018-12, Vol.41 (10), p.955-962
Hauptverfasser:	Saint-Jean, A., Reguart, N., Eixarch, A., Adán, A., Castellà, C., Sánchez-Dalmau, B., Sainz–de–la–Maza, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Administration, Oral Aged Aged, 80 and over Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Camptothecin - analogs & derivatives Camptothecin - therapeutic use Case-Control Studies Chemotherapy Chimiothérapie Colorectal Neoplasms - drug therapy Confocal microscopy Cornea Cornea - diagnostic imaging Cornea - drug effects Cornea - pathology Cornée Dry Eye Syndromes - chemically induced Dry Eye Syndromes - pathology Effets secondaires sur la surface oculaire Epidermal growth factor receptor inhibitors ErbB Receptors - antagonists & inhibitors ErbB Receptors - immunology Female Fluorouracil - therapeutic use Humans Inhibiteurs du récepteur du facteur de la croissance épidermique Leucovorin - therapeutic use Lung Neoplasms - drug therapy Male Microscopie confocale Middle Aged Ocular surface secondary effects Organoplatinum Compounds - therapeutic use Prospective Studies Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - adverse effects
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