Targeting the Intrinsically Disordered Proteome Using Small-Molecule Ligands

Intrinsically disordered proteins (IDPs) and regions (IDRs) make up a significant part of the proteome and facilitate a wide range of physiological and pathological functions that are only beginning to be understood. As such, they are highly attractive targets for drug development and bioengineering...

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Veröffentlicht in:	Methods in enzymology 2018, Vol.611, p.703-734
Hauptverfasser:	Wójcik, Sławomir, Birol, Melissa, Rhoades, Elizabeth, Miranker, Andrew D, Levine, Zachary A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Drug Discovery - methods Humans Intrinsically Disordered Proteins - chemistry Intrinsically Disordered Proteins - metabolism Ligands Models, Molecular Nuclear Magnetic Resonance, Biomolecular - methods Protein Aggregates - drug effects Protein Conformation Proteomics - methods Spectrometry, Fluorescence - methods Thermodynamics
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