Melatonin-induced demethylation of antioxidant genes increases antioxidant capacity through RORα in cumulus cells of prepubertal lambs

Physical damage and oxidative stress may occur in prepubertal cumulus cells, due to insufficient glutathione synthesis. To determine potential epigenetic mechanisms related to antioxidant effects of melatonin on ovine prepubertal cumulus cells, 30 lambs, 4-wk-old were randomly allocated into two gro...

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Veröffentlicht in:	Free radical biology & medicine 2019-02, Vol.131, p.173-183
Hauptverfasser:	Fang, Yi, Zhang, Jinlong, Li, Yihai, Guo, Xiaofei, Li, Junjie, Zhong, Rongzhen, Zhang, Xiaosheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorbable Implants Animals Antioxidant Antioxidants - pharmacology C-Reactive Protein - genetics C-Reactive Protein - metabolism Catalase - genetics Catalase - metabolism Cell Proliferation - drug effects Cumulus cells Cumulus Cells - cytology Cumulus Cells - drug effects Cumulus Cells - metabolism Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Epigenesis, Genetic Female Follicle Stimulating Hormone - pharmacology Glutathione - metabolism Hyaluronan Synthases - genetics Hyaluronan Synthases - metabolism Lamb Melatonin Melatonin - pharmacology Methylation Nuclear Receptor Subfamily 1, Group F, Member 1 - genetics Nuclear Receptor Subfamily 1, Group F, Member 1 - metabolism Phospholipid Hydroperoxide Glutathione Peroxidase - genetics Phospholipid Hydroperoxide Glutathione Peroxidase - metabolism Primary Cell Culture Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Receptors, Melatonin - genetics Receptors, Melatonin - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Serum Amyloid P-Component - genetics Serum Amyloid P-Component - metabolism Sexual Maturation - physiology Sheep Superovulation - drug effects Superoxide Dismutase-1 - genetics Superoxide Dismutase-1 - metabolism
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