Intranasal delivery of hGDNF plasmid DNA nanoparticles results in long-term and widespread transfection of perivascular cells in rat brain

The intranasal route of administration allows large therapeutics to circumvent the blood–brain barrier and be delivered directly to the CNS. Here we examined the distribution and pattern of cellular transfection, and the time course of transgene expression, in the rat brain after intranasal delivery...

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Veröffentlicht in:	Nanomedicine 2019-02, Vol.16, p.20-33
Hauptverfasser:	Aly, Amirah E-E., Harmon, Brendan, Padegimas, Linas, Sesenoglu-Laird, Ozge, Cooper, Mark J., Yurek, David M., Waszczak, Barbara L.
Format:	Artikel
Sprache:	eng
Schlagworte:	GDNF Gene therapy Intranasal Nanoparticles Pericytes
Online-Zugang:	Volltext
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