Hydralazine protects against renal ischemia-reperfusion injury in rats

In this study, we investigated whether hydralazine could reduce renal ischemia and reperfusion (I/R) injury in rats. Renal I/R was induced by a 70-min occlusion of the bilateral renal arteries and a 24-h reperfusion, which was confirmed by the increased the mortality, the levels of blood urea nitrog...

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Veröffentlicht in:	European journal of pharmacology 2019-01, Vol.843, p.199-209
Hauptverfasser:	Li, Yong, Hou, Daorong, Chen, Xuguan, Zhu, Jingfeng, Zhang, Ruyi, Sun, Wei, Li, Peng, Tian, Yunfan, Kong, Xiangqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute kidney injury Animals Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Cell Line Cytokines - blood Cytokines - genetics Hydralazine Hydralazine - pharmacology Hydralazine - therapeutic use Inflammatory cytokines Kidney - drug effects Kidney - metabolism Kidney - pathology Male Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Oxidative stress Oxidative Stress - drug effects Protective Agents - pharmacology Protective Agents - therapeutic use Rats, Sprague-Dawley Renal ischemia and reperfusion Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Reperfusion Injury - pathology
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