Low N-terminal pro-brain natriuretic peptide levels are associated with non-alcoholic fatty liver disease in patients with type 2 diabetes
Natriuretic peptides (NPs) have emerged as important regulators of lipid metabolism. Reduced levels of NPs are reported in obesity and in patients with type 2 diabetes (T2D). This NP deficiency may affect their ectopic fat distribution and lead to high risk of non-alcoholic fatty liver disease (NAFL...
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| Veröffentlicht in: | Diabetes & metabolism 2019-10, Vol.45 (5), p.429-435 |
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| creator | Johansen, M.L. Schou, M. Rasmussen, J. Rossignol, P. Holm, M.R. Chabanova, E. Dela, F. Faber, J. Kistorp, C. |
| description | Natriuretic peptides (NPs) have emerged as important regulators of lipid metabolism. Reduced levels of NPs are reported in obesity and in patients with type 2 diabetes (T2D). This NP deficiency may affect their ectopic fat distribution and lead to high risk of non-alcoholic fatty liver disease (NAFLD).
In this cross-sectional study, the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and liver fat content was quantified using 1H-magnetic resonance spectroscopy in 120 patients with T2D.
NAFLD (defined as liver fat content ≥ 5.6%) was found in 57 (48%) of the T2D patients, who also had significantly lower NT-proBNP (P = 0.002) levels compared with patients without NAFLD, but did not differ as regards the presence of cardiovascular disease (CVD) or in kidney function. After adjusting for potential confounders (age, gender, HbA1c, BMI, HOMA2-IR, CVD, eGFR), the odds ratio for the presence of NAFLD was increased by 2.9 (P = 0.048) for NT-proBNP levels |
| doi_str_mv | 10.1016/j.diabet.2018.11.003 |
| format | Article |
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In this cross-sectional study, the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and liver fat content was quantified using 1H-magnetic resonance spectroscopy in 120 patients with T2D.
NAFLD (defined as liver fat content ≥ 5.6%) was found in 57 (48%) of the T2D patients, who also had significantly lower NT-proBNP (P = 0.002) levels compared with patients without NAFLD, but did not differ as regards the presence of cardiovascular disease (CVD) or in kidney function. After adjusting for potential confounders (age, gender, HbA1c, BMI, HOMA2-IR, CVD, eGFR), the odds ratio for the presence of NAFLD was increased by 2.9 (P = 0.048) for NT-proBNP levels < 45 ng/L. In a multivariable linear regression model, the relationship with NT-proBNP was further analyzed as a continuous variable, and was independently and inversely associated with increasing liver fat content after full adjustment (P = 0.031).
Reduced plasma NT-proBNP levels are independently associated with high liver fat content in patients with T2D. The present study suggests that NP deficiency may play a role in the development of NAFLD in T2D.</description><identifier>ISSN: 1262-3636</identifier><identifier>EISSN: 1878-1780</identifier><identifier>DOI: 10.1016/j.diabet.2018.11.003</identifier><identifier>PMID: 30472196</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Absorptiometry, Photon ; Adipose Tissue - diagnostic imaging ; Aged ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - diagnostic imaging ; Female ; Humans ; Liver - diagnostic imaging ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged ; Natriuretic peptide ; Natriuretic Peptide, Brain - blood ; Non-alcoholic fatty liver disease ; Non-alcoholic Fatty Liver Disease - blood ; Non-alcoholic Fatty Liver Disease - complications ; Non-alcoholic Fatty Liver Disease - diagnostic imaging ; Peptide Fragments - blood ; Type 2 diabetes</subject><ispartof>Diabetes & metabolism, 2019-10, Vol.45 (5), p.429-435</ispartof><rights>2018 Elsevier Masson SAS</rights><rights>Copyright © 2018 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-5c876f14c40ef257d5a59c4d5750e507c2cb91f5f190cb419e73b07c26f625d13</citedby><cites>FETCH-LOGICAL-c362t-5c876f14c40ef257d5a59c4d5750e507c2cb91f5f190cb419e73b07c26f625d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1262363618302180$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30472196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johansen, M.L.</creatorcontrib><creatorcontrib>Schou, M.</creatorcontrib><creatorcontrib>Rasmussen, J.</creatorcontrib><creatorcontrib>Rossignol, P.</creatorcontrib><creatorcontrib>Holm, M.R.</creatorcontrib><creatorcontrib>Chabanova, E.</creatorcontrib><creatorcontrib>Dela, F.</creatorcontrib><creatorcontrib>Faber, J.</creatorcontrib><creatorcontrib>Kistorp, C.</creatorcontrib><title>Low N-terminal pro-brain natriuretic peptide levels are associated with non-alcoholic fatty liver disease in patients with type 2 diabetes</title><title>Diabetes & metabolism</title><addtitle>Diabetes Metab</addtitle><description>Natriuretic peptides (NPs) have emerged as important regulators of lipid metabolism. Reduced levels of NPs are reported in obesity and in patients with type 2 diabetes (T2D). This NP deficiency may affect their ectopic fat distribution and lead to high risk of non-alcoholic fatty liver disease (NAFLD).
In this cross-sectional study, the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and liver fat content was quantified using 1H-magnetic resonance spectroscopy in 120 patients with T2D.
NAFLD (defined as liver fat content ≥ 5.6%) was found in 57 (48%) of the T2D patients, who also had significantly lower NT-proBNP (P = 0.002) levels compared with patients without NAFLD, but did not differ as regards the presence of cardiovascular disease (CVD) or in kidney function. After adjusting for potential confounders (age, gender, HbA1c, BMI, HOMA2-IR, CVD, eGFR), the odds ratio for the presence of NAFLD was increased by 2.9 (P = 0.048) for NT-proBNP levels < 45 ng/L. In a multivariable linear regression model, the relationship with NT-proBNP was further analyzed as a continuous variable, and was independently and inversely associated with increasing liver fat content after full adjustment (P = 0.031).
Reduced plasma NT-proBNP levels are independently associated with high liver fat content in patients with T2D. The present study suggests that NP deficiency may play a role in the development of NAFLD in T2D.</description><subject>Absorptiometry, Photon</subject><subject>Adipose Tissue - diagnostic imaging</subject><subject>Aged</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - diagnostic imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Liver - diagnostic imaging</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Natriuretic peptide</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Non-alcoholic fatty liver disease</subject><subject>Non-alcoholic Fatty Liver Disease - blood</subject><subject>Non-alcoholic Fatty Liver Disease - complications</subject><subject>Non-alcoholic Fatty Liver Disease - diagnostic imaging</subject><subject>Peptide Fragments - blood</subject><subject>Type 2 diabetes</subject><issn>1262-3636</issn><issn>1878-1780</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcuO1DAQtBCIfcAfIOQjlwS3HTvJBQmteKw0ggucLcfuaD3yxMH2zGp-ga_GoywcOXWrVdXdVUXIG2AtMFDv963zZsLScgZDC9AyJp6Raxj6oYF-YM9rzxVvhBLqitzkvGcM-CiGl-RKsK7nMKpr8nsXH-m3pmA6-MUEuqbYTMn4hS6mJH9MWLylK67FO6QBTxgyNQmpyTlabwo6-ujLA13i0phg40MMlTCbUs40-BMm6nxGk5HWnaspHpeSN0o5r0g53WRgfkVezCZkfP1Ub8nPz59-3H1tdt-_3N993DVWKF4aaYdezdDZjuHMZe-kkaPtnOwlQ8l6y-00wixnGJmdOhixF9NlrGbFpQNxS95te6vWX0fMRR98thiCWTAes-YgBtaJbpAV2m1Qm2LOCWe9Jn8w6ayB6UsKeq-39_UlBQ2gawqV9vbpwnE6oPtH-mt7BXzYANVNPHlMOttqjEXnE9qiXfT_v_AHJ3OcUQ</recordid><startdate>201910</startdate><enddate>201910</enddate><creator>Johansen, M.L.</creator><creator>Schou, M.</creator><creator>Rasmussen, J.</creator><creator>Rossignol, P.</creator><creator>Holm, M.R.</creator><creator>Chabanova, E.</creator><creator>Dela, F.</creator><creator>Faber, J.</creator><creator>Kistorp, C.</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201910</creationdate><title>Low N-terminal pro-brain natriuretic peptide levels are associated with non-alcoholic fatty liver disease in patients with type 2 diabetes</title><author>Johansen, M.L. ; Schou, M. ; Rasmussen, J. ; Rossignol, P. ; Holm, M.R. ; Chabanova, E. ; Dela, F. ; Faber, J. ; Kistorp, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-5c876f14c40ef257d5a59c4d5750e507c2cb91f5f190cb419e73b07c26f625d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Absorptiometry, Photon</topic><topic>Adipose Tissue - diagnostic imaging</topic><topic>Aged</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - diagnostic imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Liver - diagnostic imaging</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Natriuretic peptide</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>Non-alcoholic fatty liver disease</topic><topic>Non-alcoholic Fatty Liver Disease - blood</topic><topic>Non-alcoholic Fatty Liver Disease - complications</topic><topic>Non-alcoholic Fatty Liver Disease - diagnostic imaging</topic><topic>Peptide Fragments - blood</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johansen, M.L.</creatorcontrib><creatorcontrib>Schou, M.</creatorcontrib><creatorcontrib>Rasmussen, J.</creatorcontrib><creatorcontrib>Rossignol, P.</creatorcontrib><creatorcontrib>Holm, M.R.</creatorcontrib><creatorcontrib>Chabanova, E.</creatorcontrib><creatorcontrib>Dela, F.</creatorcontrib><creatorcontrib>Faber, J.</creatorcontrib><creatorcontrib>Kistorp, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes & metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johansen, M.L.</au><au>Schou, M.</au><au>Rasmussen, J.</au><au>Rossignol, P.</au><au>Holm, M.R.</au><au>Chabanova, E.</au><au>Dela, F.</au><au>Faber, J.</au><au>Kistorp, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low N-terminal pro-brain natriuretic peptide levels are associated with non-alcoholic fatty liver disease in patients with type 2 diabetes</atitle><jtitle>Diabetes & metabolism</jtitle><addtitle>Diabetes Metab</addtitle><date>2019-10</date><risdate>2019</risdate><volume>45</volume><issue>5</issue><spage>429</spage><epage>435</epage><pages>429-435</pages><issn>1262-3636</issn><eissn>1878-1780</eissn><abstract>Natriuretic peptides (NPs) have emerged as important regulators of lipid metabolism. Reduced levels of NPs are reported in obesity and in patients with type 2 diabetes (T2D). This NP deficiency may affect their ectopic fat distribution and lead to high risk of non-alcoholic fatty liver disease (NAFLD).
In this cross-sectional study, the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and liver fat content was quantified using 1H-magnetic resonance spectroscopy in 120 patients with T2D.
NAFLD (defined as liver fat content ≥ 5.6%) was found in 57 (48%) of the T2D patients, who also had significantly lower NT-proBNP (P = 0.002) levels compared with patients without NAFLD, but did not differ as regards the presence of cardiovascular disease (CVD) or in kidney function. After adjusting for potential confounders (age, gender, HbA1c, BMI, HOMA2-IR, CVD, eGFR), the odds ratio for the presence of NAFLD was increased by 2.9 (P = 0.048) for NT-proBNP levels < 45 ng/L. In a multivariable linear regression model, the relationship with NT-proBNP was further analyzed as a continuous variable, and was independently and inversely associated with increasing liver fat content after full adjustment (P = 0.031).
Reduced plasma NT-proBNP levels are independently associated with high liver fat content in patients with T2D. The present study suggests that NP deficiency may play a role in the development of NAFLD in T2D.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>30472196</pmid><doi>10.1016/j.diabet.2018.11.003</doi><tpages>7</tpages></addata></record> |
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| ispartof | Diabetes & metabolism, 2019-10, Vol.45 (5), p.429-435 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Absorptiometry, Photon Adipose Tissue - diagnostic imaging Aged Cross-Sectional Studies Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - diagnostic imaging Female Humans Liver - diagnostic imaging Magnetic Resonance Spectroscopy Male Middle Aged Natriuretic peptide Natriuretic Peptide, Brain - blood Non-alcoholic fatty liver disease Non-alcoholic Fatty Liver Disease - blood Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - diagnostic imaging Peptide Fragments - blood Type 2 diabetes |
| title | Low N-terminal pro-brain natriuretic peptide levels are associated with non-alcoholic fatty liver disease in patients with type 2 diabetes |
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