Dynamic MCP-1 mRNA response of human aortic endothelial cells (HAEC) to step changes in laminar shear stress
Our aim is to study the hemodynamic alteration of monocyte recruitment and adhesion in model blood vessel systems, focusing on the hemodynamic effects of the recruitment factor monocyte chemotactic protein one, MCP-1, gene expression in HAEC. Preconditioning with low shear stress, LS, elevates MCP-1...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Format: | Tagungsbericht |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4 |
|---|---|
| container_issue | |
| container_start_page | 4 vol.1 |
| container_title | |
| container_volume | 1 |
| creator | Guild, J.B. Chromiak, A.B. Sprague, E.A. Nerem, R.M. |
| description | Our aim is to study the hemodynamic alteration of monocyte recruitment and adhesion in model blood vessel systems, focusing on the hemodynamic effects of the recruitment factor monocyte chemotactic protein one, MCP-1, gene expression in HAEC. Preconditioning with low shear stress, LS, elevates MCP-1 gene activity and eliminates any transient peak in activity upon switching to high shear stress, HS, without affecting HS-induced gene down-regulation. These data suggest an interaction between the pathways mediating the long term response to LS and the transient cellular response to HS onset. |
| doi_str_mv | 10.1109/IEMBS.1999.802021 |
| format | Conference Proceeding |
| fullrecord | <record><control><sourceid>proquest_6IE</sourceid><recordid>TN_cdi_proquest_miscellaneous_21379468</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ieee_id>802021</ieee_id><sourcerecordid>439438</sourcerecordid><originalsourceid>FETCH-LOGICAL-i118t-cdb98f62cff92a8f5408d9f5f93b07a96c051a2ee642c350a4928d7394e06f8b3</originalsourceid><addsrcrecordid>eNotkMtOwzAQRS0eEm3hA2DlFYJFiu3Yjr0sodBKLSAeErvITcYkKLFDnC7696Qqm5nFnDm6ughdUjKllOi75Xx9_z6lWuupIowweoRGVAgVcUnFMRqTRJFYyISrk-FANI-kSr7O0DiEHzI8EEFHqH7YOdNUOV6nrxHFzdvzDHcQWu8CYG9xuW2Mw8Z3_cCAK3xfQl2ZGudQ1wHfLGbz9Bb3HoceWpyXxn1DwJXD9WB1psOhhP3sB2k4R6fW1AEu_vcEfT7OP9JFtHp5WqazVVRRqvooLzZaWclyazUzygpOVKGtsDrekMRomQ_RDQOQnOWxIIZrpook1hyItGoTT9D1wdt2_ncLoc-aKuwDGwd-GzJG40RzqQbw6gBWAJC1XdWYbpcd2oz_AJ2dZlk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>conference_proceeding</recordtype><pqid>21379468</pqid></control><display><type>conference_proceeding</type><title>Dynamic MCP-1 mRNA response of human aortic endothelial cells (HAEC) to step changes in laminar shear stress</title><source>IEEE Electronic Library (IEL) Conference Proceedings</source><creator>Guild, J.B. ; Chromiak, A.B. ; Sprague, E.A. ; Nerem, R.M.</creator><creatorcontrib>Guild, J.B. ; Chromiak, A.B. ; Sprague, E.A. ; Nerem, R.M.</creatorcontrib><description>Our aim is to study the hemodynamic alteration of monocyte recruitment and adhesion in model blood vessel systems, focusing on the hemodynamic effects of the recruitment factor monocyte chemotactic protein one, MCP-1, gene expression in HAEC. Preconditioning with low shear stress, LS, elevates MCP-1 gene activity and eliminates any transient peak in activity upon switching to high shear stress, HS, without affecting HS-induced gene down-regulation. These data suggest an interaction between the pathways mediating the long term response to LS and the transient cellular response to HS onset.</description><identifier>ISSN: 1094-687X</identifier><identifier>ISSN: 0589-1019</identifier><identifier>ISBN: 0780356748</identifier><identifier>ISBN: 9780780356740</identifier><identifier>ISBN: 9780780356757</identifier><identifier>ISBN: 0780356756</identifier><identifier>EISSN: 1558-4615</identifier><identifier>DOI: 10.1109/IEMBS.1999.802021</identifier><language>eng</language><publisher>IEEE</publisher><subject>Biomedical engineering ; Blood vessels ; Cell culture ; Cells ; Chemical technology ; Gene expression ; Genetic engineering ; Hemodynamics ; Humans ; In vivo ; Recruitment ; RNA ; Shear stress ; Stress ; Switches</subject><ispartof>Proceedings of the First Joint BMES/EMBS Conference : serving humanity advancing technology, Oct. 13-16, 99, Atlanta, GA, USA, 1999, Vol.1, p.4 vol.1-4</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/802021$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,2058,4050,4051,27924,27925,54920</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/802021$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc></links><search><creatorcontrib>Guild, J.B.</creatorcontrib><creatorcontrib>Chromiak, A.B.</creatorcontrib><creatorcontrib>Sprague, E.A.</creatorcontrib><creatorcontrib>Nerem, R.M.</creatorcontrib><title>Dynamic MCP-1 mRNA response of human aortic endothelial cells (HAEC) to step changes in laminar shear stress</title><title>Proceedings of the First Joint BMES/EMBS Conference : serving humanity advancing technology, Oct. 13-16, 99, Atlanta, GA, USA</title><addtitle>IEMBS</addtitle><description>Our aim is to study the hemodynamic alteration of monocyte recruitment and adhesion in model blood vessel systems, focusing on the hemodynamic effects of the recruitment factor monocyte chemotactic protein one, MCP-1, gene expression in HAEC. Preconditioning with low shear stress, LS, elevates MCP-1 gene activity and eliminates any transient peak in activity upon switching to high shear stress, HS, without affecting HS-induced gene down-regulation. These data suggest an interaction between the pathways mediating the long term response to LS and the transient cellular response to HS onset.</description><subject>Biomedical engineering</subject><subject>Blood vessels</subject><subject>Cell culture</subject><subject>Cells</subject><subject>Chemical technology</subject><subject>Gene expression</subject><subject>Genetic engineering</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>In vivo</subject><subject>Recruitment</subject><subject>RNA</subject><subject>Shear stress</subject><subject>Stress</subject><subject>Switches</subject><issn>1094-687X</issn><issn>0589-1019</issn><issn>1558-4615</issn><isbn>0780356748</isbn><isbn>9780780356740</isbn><isbn>9780780356757</isbn><isbn>0780356756</isbn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>1999</creationdate><recordtype>conference_proceeding</recordtype><sourceid>6IE</sourceid><sourceid>RIE</sourceid><recordid>eNotkMtOwzAQRS0eEm3hA2DlFYJFiu3Yjr0sodBKLSAeErvITcYkKLFDnC7696Qqm5nFnDm6ughdUjKllOi75Xx9_z6lWuupIowweoRGVAgVcUnFMRqTRJFYyISrk-FANI-kSr7O0DiEHzI8EEFHqH7YOdNUOV6nrxHFzdvzDHcQWu8CYG9xuW2Mw8Z3_cCAK3xfQl2ZGudQ1wHfLGbz9Bb3HoceWpyXxn1DwJXD9WB1psOhhP3sB2k4R6fW1AEu_vcEfT7OP9JFtHp5WqazVVRRqvooLzZaWclyazUzygpOVKGtsDrekMRomQ_RDQOQnOWxIIZrpook1hyItGoTT9D1wdt2_ncLoc-aKuwDGwd-GzJG40RzqQbw6gBWAJC1XdWYbpcd2oz_AJ2dZlk</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Guild, J.B.</creator><creator>Chromiak, A.B.</creator><creator>Sprague, E.A.</creator><creator>Nerem, R.M.</creator><general>IEEE</general><scope>6IE</scope><scope>6IH</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIO</scope></search><sort><creationdate>1999</creationdate><title>Dynamic MCP-1 mRNA response of human aortic endothelial cells (HAEC) to step changes in laminar shear stress</title><author>Guild, J.B. ; Chromiak, A.B. ; Sprague, E.A. ; Nerem, R.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i118t-cdb98f62cff92a8f5408d9f5f93b07a96c051a2ee642c350a4928d7394e06f8b3</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Biomedical engineering</topic><topic>Blood vessels</topic><topic>Cell culture</topic><topic>Cells</topic><topic>Chemical technology</topic><topic>Gene expression</topic><topic>Genetic engineering</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>In vivo</topic><topic>Recruitment</topic><topic>RNA</topic><topic>Shear stress</topic><topic>Stress</topic><topic>Switches</topic><toplevel>online_resources</toplevel><creatorcontrib>Guild, J.B.</creatorcontrib><creatorcontrib>Chromiak, A.B.</creatorcontrib><creatorcontrib>Sprague, E.A.</creatorcontrib><creatorcontrib>Nerem, R.M.</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan (POP) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Electronic Library (IEL)</collection><collection>IEEE Proceedings Order Plans (POP) 1998-present</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Guild, J.B.</au><au>Chromiak, A.B.</au><au>Sprague, E.A.</au><au>Nerem, R.M.</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Dynamic MCP-1 mRNA response of human aortic endothelial cells (HAEC) to step changes in laminar shear stress</atitle><btitle>Proceedings of the First Joint BMES/EMBS Conference : serving humanity advancing technology, Oct. 13-16, 99, Atlanta, GA, USA</btitle><stitle>IEMBS</stitle><date>1999</date><risdate>1999</risdate><volume>1</volume><spage>4 vol.1</spage><epage>4</epage><pages>4 vol.1-4</pages><issn>1094-687X</issn><issn>0589-1019</issn><eissn>1558-4615</eissn><isbn>0780356748</isbn><isbn>9780780356740</isbn><isbn>9780780356757</isbn><isbn>0780356756</isbn><abstract>Our aim is to study the hemodynamic alteration of monocyte recruitment and adhesion in model blood vessel systems, focusing on the hemodynamic effects of the recruitment factor monocyte chemotactic protein one, MCP-1, gene expression in HAEC. Preconditioning with low shear stress, LS, elevates MCP-1 gene activity and eliminates any transient peak in activity upon switching to high shear stress, HS, without affecting HS-induced gene down-regulation. These data suggest an interaction between the pathways mediating the long term response to LS and the transient cellular response to HS onset.</abstract><pub>IEEE</pub><doi>10.1109/IEMBS.1999.802021</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 1094-687X |
| ispartof | Proceedings of the First Joint BMES/EMBS Conference : serving humanity advancing technology, Oct. 13-16, 99, Atlanta, GA, USA, 1999, Vol.1, p.4 vol.1-4 |
| issn | 1094-687X 0589-1019 1558-4615 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_21379468 |
| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | Biomedical engineering Blood vessels Cell culture Cells Chemical technology Gene expression Genetic engineering Hemodynamics Humans In vivo Recruitment RNA Shear stress Stress Switches |
| title | Dynamic MCP-1 mRNA response of human aortic endothelial cells (HAEC) to step changes in laminar shear stress |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T11%3A42%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_6IE&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=proceeding&rft.atitle=Dynamic%20MCP-1%20mRNA%20response%20of%20human%20aortic%20endothelial%20cells%20(HAEC)%20to%20step%20changes%20in%20laminar%20shear%20stress&rft.btitle=Proceedings%20of%20the%20First%20Joint%20BMES/EMBS%20Conference%20:%20serving%20humanity%20advancing%20technology,%20Oct.%2013-16,%2099,%20Atlanta,%20GA,%20USA&rft.au=Guild,%20J.B.&rft.date=1999&rft.volume=1&rft.spage=4%20vol.1&rft.epage=4&rft.pages=4%20vol.1-4&rft.issn=1094-687X&rft.eissn=1558-4615&rft.isbn=0780356748&rft.isbn_list=9780780356740&rft.isbn_list=9780780356757&rft.isbn_list=0780356756&rft_id=info:doi/10.1109/IEMBS.1999.802021&rft_dat=%3Cproquest_6IE%3E439438%3C/proquest_6IE%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=21379468&rft_id=info:pmid/&rft_ieee_id=802021&rfr_iscdi=true |