Purity by design: Reducing impurities in bioproduction by stimulus-controlled global translational downregulation of non-product proteins

Capitalizing on the ability of mammalian cells to conduct complex post-translational modifications, most protein therapeutics are currently produced in cell culture systems. Addition of a signal peptide to the product protein enables its accumulation in the cell culture supernatant, but separation o...

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Veröffentlicht in:	Metabolic engineering 2019-03, Vol.52, p.110-123
Hauptverfasser:	Bojar, Daniel, Fuhrer, Tobias, Fussenegger, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopharmaceutical manufacturing Biotechnology Caffeine PKR Rituximab Synthetic biology
Online-Zugang:	Volltext
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