ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

Pyroptosis is a lytic form of cell death that is induced by inflammatory caspases upon activation of the canonical or noncanonical inflammasome pathways. These caspases cleave gasdermin D (GSDMD) to generate an N-terminal GSDMD fragment, which executes pyroptosis by forming membrane pores. We found...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2018-11, Vol.362 (6417), p.956-960
Hauptverfasser:	Rühl, Sebastian, Shkarina, Kateryna, Demarco, Benjamin, Heilig, Rosalie, Santos, José Carlos, Broz, Petr
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Aniline Compounds - metabolism Animals Apoptosis Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Calcium Calcium - metabolism Calcium influx Calcium Signaling Caspase 1 - metabolism Caspases - genetics Caspases - metabolism Cell death Cell Membrane - metabolism Cell Survival Cells, Cultured Endosomal Sorting Complexes Required for Transport - metabolism Fluorescent Dyes - metabolism HEK293 Cells Humans IL-1β Inflammasomes Inflammation Inflammation - metabolism Inflammation - pathology Interleukin-1beta - metabolism Interleukins Machinery and equipment Macrophages Membrane permeability Mice Mortality Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Pores Porosity Pyroptosis Repair Xanthenes - metabolism
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