Masseter muscle atrophy impairs bone quality of the mandibular condyle but not the alveolar process early after induction
Summary Background Masseter muscle function influences mandibular bone homeostasis. As previously reported, bone resorption markers increased in the mouse mandibular condyle two days after masseter paralysis induced with botulinum toxin type A (BoNTA), followed by local bone loss. Objective This stu...
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| Veröffentlicht in: | Journal of oral rehabilitation 2019-03, Vol.46 (3), p.233-241 |
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| creator | Balanta‐Melo, Julián Torres‐Quintana, María Angélica Bemmann, Maximilian Vega, Carolina González, Constanza Kupczik, Kornelius Toro‐Ibacache, Viviana Buvinic, Sonja |
| description | Summary
Background
Masseter muscle function influences mandibular bone homeostasis. As previously reported, bone resorption markers increased in the mouse mandibular condyle two days after masseter paralysis induced with botulinum toxin type A (BoNTA), followed by local bone loss.
Objective
This study aimed to evaluate the bone quality of both the mandibular condyle and alveolar process in the mandible of adult mice during the early stage of a BoNTA‐induced masseter muscle atrophy, using a combined 3D histomorphometrics and shape analysis approach.
Methods
Adult BALB/c mice were divided into an untreated control group and an experimental group; the latter received one single BoNTA injection in the right masseter (BoNTA‐right) and saline in the left masseter (Saline‐left). 3D bone microstructural changes in the mandibular condyle and alveolar process were determined with high‐resolution microtomography. Additionally, landmark‐based geometric morphometrics was implemented to assess external shape changes.
Results
After 2 weeks, masseter mass was significantly reduced (P‐value |
| doi_str_mv | 10.1111/joor.12747 |
| format | Article |
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Background
Masseter muscle function influences mandibular bone homeostasis. As previously reported, bone resorption markers increased in the mouse mandibular condyle two days after masseter paralysis induced with botulinum toxin type A (BoNTA), followed by local bone loss.
Objective
This study aimed to evaluate the bone quality of both the mandibular condyle and alveolar process in the mandible of adult mice during the early stage of a BoNTA‐induced masseter muscle atrophy, using a combined 3D histomorphometrics and shape analysis approach.
Methods
Adult BALB/c mice were divided into an untreated control group and an experimental group; the latter received one single BoNTA injection in the right masseter (BoNTA‐right) and saline in the left masseter (Saline‐left). 3D bone microstructural changes in the mandibular condyle and alveolar process were determined with high‐resolution microtomography. Additionally, landmark‐based geometric morphometrics was implemented to assess external shape changes.
Results
After 2 weeks, masseter mass was significantly reduced (P‐value <0.001). When compared to Saline‐left and untreated condyles, BoNTA‐right condyles showed significant bone loss (P‐value <0.001) and shape changes. No significant bone loss was observed in the alveolar processes of any of the groups (P‐value >0.05).
Conclusion
Condyle bone quality deteriorates at an early stage of BoNTA‐induced masseter muscle atrophy, and before the alveolar process is affected. Since the observed bone microstructural changes resemble those in human temporomandibular joint degenerative disorders, the clinical safety of BoNTA intervention in the masticatory apparatus remains to be clarified.</description><identifier>ISSN: 0305-182X</identifier><identifier>EISSN: 1365-2842</identifier><identifier>DOI: 10.1111/joor.12747</identifier><identifier>PMID: 30468522</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>alveolar process ; Animals ; Atrophy ; Atrophy - chemically induced ; Atrophy - pathology ; Bone Density - drug effects ; Bone loss ; Bone resorption ; Bone Resorption - chemically induced ; Bone Resorption - pathology ; Bone turnover ; Botulinum toxin ; Botulinum toxin type A ; botulinum toxins type A ; Botulinum Toxins, Type A - pharmacology ; Disease Models, Animal ; Homeostasis ; Male ; Mandible ; mandibular condyle ; Mandibular Condyle - pathology ; Masseter muscle ; Masseter Muscle - pathology ; Mastication ; masticatory muscles ; Mice ; Mice, Inbred BALB C ; Morphometry ; Paralysis ; Temporomandibular joint</subject><ispartof>Journal of oral rehabilitation, 2019-03, Vol.46 (3), p.233-241</ispartof><rights>2018 John Wiley & Sons Ltd</rights><rights>2018 John Wiley & Sons Ltd.</rights><rights>Copyright © 2019 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3837-fb78d0a7094db0257db3895199fb9f2c59d8cdb61b97eb7e888cbbbe80870f3b3</citedby><cites>FETCH-LOGICAL-c3837-fb78d0a7094db0257db3895199fb9f2c59d8cdb61b97eb7e888cbbbe80870f3b3</cites><orcidid>0000-0002-0138-9199 ; 0000-0003-2265-8180 ; 0000-0002-2286-2918</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjoor.12747$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjoor.12747$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30468522$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Balanta‐Melo, Julián</creatorcontrib><creatorcontrib>Torres‐Quintana, María Angélica</creatorcontrib><creatorcontrib>Bemmann, Maximilian</creatorcontrib><creatorcontrib>Vega, Carolina</creatorcontrib><creatorcontrib>González, Constanza</creatorcontrib><creatorcontrib>Kupczik, Kornelius</creatorcontrib><creatorcontrib>Toro‐Ibacache, Viviana</creatorcontrib><creatorcontrib>Buvinic, Sonja</creatorcontrib><title>Masseter muscle atrophy impairs bone quality of the mandibular condyle but not the alveolar process early after induction</title><title>Journal of oral rehabilitation</title><addtitle>J Oral Rehabil</addtitle><description>Summary
Background
Masseter muscle function influences mandibular bone homeostasis. As previously reported, bone resorption markers increased in the mouse mandibular condyle two days after masseter paralysis induced with botulinum toxin type A (BoNTA), followed by local bone loss.
Objective
This study aimed to evaluate the bone quality of both the mandibular condyle and alveolar process in the mandible of adult mice during the early stage of a BoNTA‐induced masseter muscle atrophy, using a combined 3D histomorphometrics and shape analysis approach.
Methods
Adult BALB/c mice were divided into an untreated control group and an experimental group; the latter received one single BoNTA injection in the right masseter (BoNTA‐right) and saline in the left masseter (Saline‐left). 3D bone microstructural changes in the mandibular condyle and alveolar process were determined with high‐resolution microtomography. Additionally, landmark‐based geometric morphometrics was implemented to assess external shape changes.
Results
After 2 weeks, masseter mass was significantly reduced (P‐value <0.001). When compared to Saline‐left and untreated condyles, BoNTA‐right condyles showed significant bone loss (P‐value <0.001) and shape changes. No significant bone loss was observed in the alveolar processes of any of the groups (P‐value >0.05).
Conclusion
Condyle bone quality deteriorates at an early stage of BoNTA‐induced masseter muscle atrophy, and before the alveolar process is affected. Since the observed bone microstructural changes resemble those in human temporomandibular joint degenerative disorders, the clinical safety of BoNTA intervention in the masticatory apparatus remains to be clarified.</description><subject>alveolar process</subject><subject>Animals</subject><subject>Atrophy</subject><subject>Atrophy - chemically induced</subject><subject>Atrophy - pathology</subject><subject>Bone Density - drug effects</subject><subject>Bone loss</subject><subject>Bone resorption</subject><subject>Bone Resorption - chemically induced</subject><subject>Bone Resorption - pathology</subject><subject>Bone turnover</subject><subject>Botulinum toxin</subject><subject>Botulinum toxin type A</subject><subject>botulinum toxins type A</subject><subject>Botulinum Toxins, Type A - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Homeostasis</subject><subject>Male</subject><subject>Mandible</subject><subject>mandibular condyle</subject><subject>Mandibular Condyle - pathology</subject><subject>Masseter muscle</subject><subject>Masseter Muscle - pathology</subject><subject>Mastication</subject><subject>masticatory muscles</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Morphometry</subject><subject>Paralysis</subject><subject>Temporomandibular joint</subject><issn>0305-182X</issn><issn>1365-2842</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90cuKFDEUBuAgitMzuvEBJOBGBmo8Sao6qaUMXhlpEAV3RS6nmDSpSk9SUertTU-PLlyYTRbny58DPyEvGFyxet7sY0xXjMtWPiIbJrZdw1XLH5MNCOgapviPM3Ke8x4AlOjkU3ImoN2qjvMNWb_onHHBRKeSbUCqlxQPtyv100H7lKmJM9K7ooNfVhpHutwinfTsvClBJ2rj7Nb6zJSFznG5H-vwE-NxeEjRYs4UdQor1ePxGz-7Yhcf52fkyahDxucP9wX5_v7dt-uPzc3uw6frtzeNFUrIZjRSOdAS-tYZ4J10Rqi-Y30_mn7ktuudss5smeklGolKKWuMQQVKwiiMuCCvT7l1m7uCeRkmny2GoGeMJQ-cCdlu27aVlb76h-5jSXPdrioF0ANXUNXlSdkUc044DofkJ53WgcFwLGQ4FjLcF1Lxy4fIYiZ0f-mfBipgJ_DLB1z_EzV83u2-nkJ_AwLmmEE</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Balanta‐Melo, Julián</creator><creator>Torres‐Quintana, María Angélica</creator><creator>Bemmann, Maximilian</creator><creator>Vega, Carolina</creator><creator>González, Constanza</creator><creator>Kupczik, Kornelius</creator><creator>Toro‐Ibacache, Viviana</creator><creator>Buvinic, Sonja</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0138-9199</orcidid><orcidid>https://orcid.org/0000-0003-2265-8180</orcidid><orcidid>https://orcid.org/0000-0002-2286-2918</orcidid></search><sort><creationdate>201903</creationdate><title>Masseter muscle atrophy impairs bone quality of the mandibular condyle but not the alveolar process early after induction</title><author>Balanta‐Melo, Julián ; Torres‐Quintana, María Angélica ; Bemmann, Maximilian ; Vega, Carolina ; González, Constanza ; Kupczik, Kornelius ; Toro‐Ibacache, Viviana ; Buvinic, Sonja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3837-fb78d0a7094db0257db3895199fb9f2c59d8cdb61b97eb7e888cbbbe80870f3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>alveolar process</topic><topic>Animals</topic><topic>Atrophy</topic><topic>Atrophy - chemically induced</topic><topic>Atrophy - pathology</topic><topic>Bone Density - drug effects</topic><topic>Bone loss</topic><topic>Bone resorption</topic><topic>Bone Resorption - chemically induced</topic><topic>Bone Resorption - pathology</topic><topic>Bone turnover</topic><topic>Botulinum toxin</topic><topic>Botulinum toxin type A</topic><topic>botulinum toxins type A</topic><topic>Botulinum Toxins, Type A - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Homeostasis</topic><topic>Male</topic><topic>Mandible</topic><topic>mandibular condyle</topic><topic>Mandibular Condyle - pathology</topic><topic>Masseter muscle</topic><topic>Masseter Muscle - pathology</topic><topic>Mastication</topic><topic>masticatory muscles</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Morphometry</topic><topic>Paralysis</topic><topic>Temporomandibular joint</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balanta‐Melo, Julián</creatorcontrib><creatorcontrib>Torres‐Quintana, María Angélica</creatorcontrib><creatorcontrib>Bemmann, Maximilian</creatorcontrib><creatorcontrib>Vega, Carolina</creatorcontrib><creatorcontrib>González, Constanza</creatorcontrib><creatorcontrib>Kupczik, Kornelius</creatorcontrib><creatorcontrib>Toro‐Ibacache, Viviana</creatorcontrib><creatorcontrib>Buvinic, Sonja</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balanta‐Melo, Julián</au><au>Torres‐Quintana, María Angélica</au><au>Bemmann, Maximilian</au><au>Vega, Carolina</au><au>González, Constanza</au><au>Kupczik, Kornelius</au><au>Toro‐Ibacache, Viviana</au><au>Buvinic, Sonja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Masseter muscle atrophy impairs bone quality of the mandibular condyle but not the alveolar process early after induction</atitle><jtitle>Journal of oral rehabilitation</jtitle><addtitle>J Oral Rehabil</addtitle><date>2019-03</date><risdate>2019</risdate><volume>46</volume><issue>3</issue><spage>233</spage><epage>241</epage><pages>233-241</pages><issn>0305-182X</issn><eissn>1365-2842</eissn><abstract>Summary
Background
Masseter muscle function influences mandibular bone homeostasis. As previously reported, bone resorption markers increased in the mouse mandibular condyle two days after masseter paralysis induced with botulinum toxin type A (BoNTA), followed by local bone loss.
Objective
This study aimed to evaluate the bone quality of both the mandibular condyle and alveolar process in the mandible of adult mice during the early stage of a BoNTA‐induced masseter muscle atrophy, using a combined 3D histomorphometrics and shape analysis approach.
Methods
Adult BALB/c mice were divided into an untreated control group and an experimental group; the latter received one single BoNTA injection in the right masseter (BoNTA‐right) and saline in the left masseter (Saline‐left). 3D bone microstructural changes in the mandibular condyle and alveolar process were determined with high‐resolution microtomography. Additionally, landmark‐based geometric morphometrics was implemented to assess external shape changes.
Results
After 2 weeks, masseter mass was significantly reduced (P‐value <0.001). When compared to Saline‐left and untreated condyles, BoNTA‐right condyles showed significant bone loss (P‐value <0.001) and shape changes. No significant bone loss was observed in the alveolar processes of any of the groups (P‐value >0.05).
Conclusion
Condyle bone quality deteriorates at an early stage of BoNTA‐induced masseter muscle atrophy, and before the alveolar process is affected. Since the observed bone microstructural changes resemble those in human temporomandibular joint degenerative disorders, the clinical safety of BoNTA intervention in the masticatory apparatus remains to be clarified.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30468522</pmid><doi>10.1111/joor.12747</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0138-9199</orcidid><orcidid>https://orcid.org/0000-0003-2265-8180</orcidid><orcidid>https://orcid.org/0000-0002-2286-2918</orcidid></addata></record> |
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| ispartof | Journal of oral rehabilitation, 2019-03, Vol.46 (3), p.233-241 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | alveolar process Animals Atrophy Atrophy - chemically induced Atrophy - pathology Bone Density - drug effects Bone loss Bone resorption Bone Resorption - chemically induced Bone Resorption - pathology Bone turnover Botulinum toxin Botulinum toxin type A botulinum toxins type A Botulinum Toxins, Type A - pharmacology Disease Models, Animal Homeostasis Male Mandible mandibular condyle Mandibular Condyle - pathology Masseter muscle Masseter Muscle - pathology Mastication masticatory muscles Mice Mice, Inbred BALB C Morphometry Paralysis Temporomandibular joint |
| title | Masseter muscle atrophy impairs bone quality of the mandibular condyle but not the alveolar process early after induction |
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