Specific knockdown of WNT8b expression protects against phosphate‐induced calcification in vascular smooth muscle cells by inhibiting the Wnt–β‐catenin signaling pathway

In the last 10 years, the prevalence, significance, and regulatory mechanisms of vascular calcification (VC) have gained increasing recognition. The aim of this study is to explore the action of WNT8b in the development of phosphate‐induced VC through its effect on vascular smooth muscle cells (VSMC...

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Veröffentlicht in:	Journal of cellular physiology 2019-04, Vol.234 (4), p.3469-3477
Hauptverfasser:	Tian, Bin‐Yao, Yao, Li, Sheng, Zi‐Tong, Wan, Peng‐Zhi, Qiu, Xiao‐Bo, Wang, Jian, Xu, Tian‐Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - genetics Actins - metabolism Alkaline phosphatase Alkaline Phosphatase - genetics Alkaline Phosphatase - metabolism Bone morphogenetic protein 2 Calcification Calcification (ectopic) Calcium Calcium - metabolism Catenin Cells, Cultured chronic kidney disease Deposition Frizzled protein Gene Knockdown Techniques Glycerophosphate Glycerophosphates - toxicity Humans Hydroxyapatite Lithium chloride mRNA Msx2 protein Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Muscles Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology phosphate Pit1 protein Polymerase chain reaction Proteins Regulatory mechanisms (biology) Reverse transcription Ribonucleic acid RNA RNA Interference Signal transduction Signaling siRNA Smooth muscle Time Factors Vascular Calcification - genetics Vascular Calcification - metabolism Vascular Calcification - pathology Vascular Calcification - prevention & control vascular smooth muscle cell Wnt protein Wnt Proteins - genetics Wnt Proteins - metabolism Wnt Signaling Pathway WNT8b Wnt–β‐catenin signaling pathway
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