Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPARγ-NF-κB signaling pathway in rat vascular smooth muscle cells

C-reactive protein (CRP) and matrix metalloproteinase (MMP)-9 are involved in the inflammation of atherosclerosis lesions. Genistein (Gen) has been demonstrated to exert beneficial effect on the cardiovascular system. However, it remains unclear whether Gen produces anti-inflammatory effect in vascu...

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Veröffentlicht in:	Life sciences (1973) 2019-01, Vol.216, p.140-146
Hauptverfasser:	Xu, Li, Liu, Jun-tian, Li, Kai, Wang, Sheng-yu, Xu, Shouzhu
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Angiotensin II Arteriosclerosis Atherosclerosis C-reactive protein Cardiovascular system Enzyme-linked immunosorbent assay Estrogen receptors Estrogens Extracellular signal-regulated kinase Gelatinase B Genistein Inflammation Lesions Matrix metalloproteinase Matrix metalloproteinase 9 Metalloproteinase Muscles NF-κB protein Peroxisome proliferator-activated receptors Polymerase chain reaction Proteins Reverse transcription Signal transduction Smooth muscle Time dependence Vascular smooth muscle cells
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