A single peri-sciatic nerve administration of the adenosine 2A receptor agonist ATL313 produces long-lasting anti-allodynia and anti-inflammatory effects in male rats

•Prior work showed that intrathecal A2a agonists produced long term pain suppression.•This study explores efficacy of the A2a agonist ATL313 at the site of nerve injury.•A single peri-sciatic ATL313 dose created long-term suppression of neuropathic pain.•Pain suppression correlated with decreased sc...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2019-02, Vol.76, p.116-125
Hauptverfasser:	Kwilasz, Andrew J., Green Fulgham, Suzanne M., Ellis, Amanda, Patel, Hardik P., Duran-Malle, Julissa Chante, Favret, Jacob, Harvey, Lewis O., Rieger, Jayson, Maier, Steven F., Watkins, Linda R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine 2A receptor Animals Cytokines - metabolism GFAP Hyperalgesia - drug therapy Iba1 Inflammation Inflammation - drug therapy Injections, Spinal - methods iNOS Interleukin-1beta Male Mechanical allodynia Neuralgia - drug therapy Neuroinflammation Neuropathy Nitric oxide Peripheral Nerve Injuries Piperidines - metabolism Piperidines - pharmacology Purinergic P1 Receptor Agonists - metabolism Rat Rats Rats, Sprague-Dawley Receptors, Purinergic P1 - metabolism Sciatic nerve Sciatic Nerve - drug effects Sciatic Nerve - injuries Sciatic Neuropathy - drug therapy
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