Plasma cytokines as potential biomarkers of kidney damage in patients with systemic lupus erythematosus
Background Systemic lupus erythematosus is a heterogeneous chronic inflammatory autoimmune disorder characterized by an exacerbated expression of cytokines and chemokines in different tissues and organs. Renal involvement is a significant contributor to the morbidity and mortality of systemic lupus...
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| Veröffentlicht in: | Lupus 2019-01, Vol.28 (1), p.34-43 |
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| creator | Pacheco-Lugo, L. Sáenz-García, J. Navarro Quiroz, E González Torres, H. Fang, L. Díaz-Olmos, Y. Garavito de Egea, G. Egea Bermejo, E. Aroca Martínez, G. |
| description | Background
Systemic lupus erythematosus is a heterogeneous chronic inflammatory autoimmune disorder characterized by an exacerbated expression of cytokines and chemokines in different tissues and organs. Renal involvement is a significant contributor to the morbidity and mortality of systemic lupus erythematosus, and its diagnosis is based on renal biopsy, an invasive procedure with a high risk of complications. Therefore, the development of alternative, non-invasive diagnostic tests for kidney disease in patients with systemic lupus erythematosus is a priority.
Aim
To evaluate the plasma levels of a panel of cytokines and chemokines using multiplex xMAP technology in a cohort of Colombian patients with active and inactive systemic lupus erythematosus, and to evaluate their potential as biomarkers of renal involvement.
Results
Plasma from 40 systemic lupus erythematosus non-nephritis patients and 80 lupus nephritis patients with different levels of renal involvement were analyzed for 39 cytokines using Luminex xMAP technology. Lupus nephritis patients had significantly increased plasma eotaxin, TNF-α, interleukin-17-α, interleukin-10, and interleukin-15 as compared to the systemic lupus erythematosus non-nephritis group. Macrophage-derived chemokine, growth regulated oncogene alpha, and epidermal growth factor were significantly elevated in systemic lupus erythematosus non-nephritis patients when compared to lupus nephritis individuals. Plasma eotaxin levels allowed a discrimination between systemic lupus erythematosus non-nephritis and lupus nephritis patients, for which we performed a receiver operating characteristic curve to confirm. We observed a correlation of eotaxin levels with active nephritis (Systemic Lupus Erythematosus Disease Activity Index). Our data indicate that circulating cytokines and chemokines could be considered good predictors of renal involvement in individuals with systemic lupus erythematosus. |
| doi_str_mv | 10.1177/0961203318812679 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2136056948</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0961203318812679</sage_id><sourcerecordid>2159551043</sourcerecordid><originalsourceid>FETCH-LOGICAL-c407t-5a59ce6f61b969d5c58c2632f2ceb1c550d1c7d21bf789883bd9fd52330572c23</originalsourceid><addsrcrecordid>eNp1kUtL5UAQhRsZ0etj72pomI2baD_Sr6XIjAqCLnQdOp2OtjdJx1QHyb-3L1cdEFwVVH3nVHEKoRNKzihV6pwYSRnhnGpNmVRmB61oqVSR--wXWm3GxWa-jw4AXgghnBq5h_Y5KQXXVK_Q031nobfYLSmuw-ABW8BjTH5IwXa4DrG309pPgGOL16EZ_IIb29snj8OAR5tCJgG_hfSMYYHk--BwN48zYD8t6dn3NkWY4QjttrYDf_xRD9Hjv78Pl9fF7d3VzeXFbeFKolIhrDDOy1bS2kjTCCe0Y5KzljlfUycEaahTDaN1q7TRmteNaRvBOCdCMcf4ITrd-o5TfJ09pKoP4HzX2cHHGSpGuSRCmlJn9M839CXO05Cvy5QwQlBS8kyRLeWmCDD5thqnkDNZKkqqzROq70_Ikt8fxnPd--ZL8Jl6BootADnH_1t_NHwH5OKPRQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2159551043</pqid></control><display><type>article</type><title>Plasma cytokines as potential biomarkers of kidney damage in patients with systemic lupus erythematosus</title><source>SAGE Complete A-Z List</source><creator>Pacheco-Lugo, L. ; Sáenz-García, J. ; Navarro Quiroz, E ; González Torres, H. ; Fang, L. ; Díaz-Olmos, Y. ; Garavito de Egea, G. ; Egea Bermejo, E. ; Aroca Martínez, G.</creator><creatorcontrib>Pacheco-Lugo, L. ; Sáenz-García, J. ; Navarro Quiroz, E ; González Torres, H. ; Fang, L. ; Díaz-Olmos, Y. ; Garavito de Egea, G. ; Egea Bermejo, E. ; Aroca Martínez, G.</creatorcontrib><description>Background
Systemic lupus erythematosus is a heterogeneous chronic inflammatory autoimmune disorder characterized by an exacerbated expression of cytokines and chemokines in different tissues and organs. Renal involvement is a significant contributor to the morbidity and mortality of systemic lupus erythematosus, and its diagnosis is based on renal biopsy, an invasive procedure with a high risk of complications. Therefore, the development of alternative, non-invasive diagnostic tests for kidney disease in patients with systemic lupus erythematosus is a priority.
Aim
To evaluate the plasma levels of a panel of cytokines and chemokines using multiplex xMAP technology in a cohort of Colombian patients with active and inactive systemic lupus erythematosus, and to evaluate their potential as biomarkers of renal involvement.
Results
Plasma from 40 systemic lupus erythematosus non-nephritis patients and 80 lupus nephritis patients with different levels of renal involvement were analyzed for 39 cytokines using Luminex xMAP technology. Lupus nephritis patients had significantly increased plasma eotaxin, TNF-α, interleukin-17-α, interleukin-10, and interleukin-15 as compared to the systemic lupus erythematosus non-nephritis group. Macrophage-derived chemokine, growth regulated oncogene alpha, and epidermal growth factor were significantly elevated in systemic lupus erythematosus non-nephritis patients when compared to lupus nephritis individuals. Plasma eotaxin levels allowed a discrimination between systemic lupus erythematosus non-nephritis and lupus nephritis patients, for which we performed a receiver operating characteristic curve to confirm. We observed a correlation of eotaxin levels with active nephritis (Systemic Lupus Erythematosus Disease Activity Index). Our data indicate that circulating cytokines and chemokines could be considered good predictors of renal involvement in individuals with systemic lupus erythematosus.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/0961203318812679</identifier><identifier>PMID: 30453818</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Biomarkers ; Biopsy ; Chemokines ; Cytokines ; Eotaxin ; Epidermal growth factor ; Interleukin 10 ; Interleukin 15 ; Interleukin 17 ; Kidneys ; Lupus ; Lupus nephritis ; Macrophage-derived chemokine ; Morbidity ; Nephritis ; Plasma ; Plasma levels ; Regression analysis ; Systemic lupus erythematosus ; Tumor necrosis factor-α</subject><ispartof>Lupus, 2019-01, Vol.28 (1), p.34-43</ispartof><rights>The Author(s) 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-5a59ce6f61b969d5c58c2632f2ceb1c550d1c7d21bf789883bd9fd52330572c23</citedby><cites>FETCH-LOGICAL-c407t-5a59ce6f61b969d5c58c2632f2ceb1c550d1c7d21bf789883bd9fd52330572c23</cites><orcidid>0000-0001-7567-6409 ; 0000-0002-9222-3257</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0961203318812679$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0961203318812679$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21818,27923,27924,43620,43621</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30453818$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pacheco-Lugo, L.</creatorcontrib><creatorcontrib>Sáenz-García, J.</creatorcontrib><creatorcontrib>Navarro Quiroz, E</creatorcontrib><creatorcontrib>González Torres, H.</creatorcontrib><creatorcontrib>Fang, L.</creatorcontrib><creatorcontrib>Díaz-Olmos, Y.</creatorcontrib><creatorcontrib>Garavito de Egea, G.</creatorcontrib><creatorcontrib>Egea Bermejo, E.</creatorcontrib><creatorcontrib>Aroca Martínez, G.</creatorcontrib><title>Plasma cytokines as potential biomarkers of kidney damage in patients with systemic lupus erythematosus</title><title>Lupus</title><addtitle>Lupus</addtitle><description>Background
Systemic lupus erythematosus is a heterogeneous chronic inflammatory autoimmune disorder characterized by an exacerbated expression of cytokines and chemokines in different tissues and organs. Renal involvement is a significant contributor to the morbidity and mortality of systemic lupus erythematosus, and its diagnosis is based on renal biopsy, an invasive procedure with a high risk of complications. Therefore, the development of alternative, non-invasive diagnostic tests for kidney disease in patients with systemic lupus erythematosus is a priority.
Aim
To evaluate the plasma levels of a panel of cytokines and chemokines using multiplex xMAP technology in a cohort of Colombian patients with active and inactive systemic lupus erythematosus, and to evaluate their potential as biomarkers of renal involvement.
Results
Plasma from 40 systemic lupus erythematosus non-nephritis patients and 80 lupus nephritis patients with different levels of renal involvement were analyzed for 39 cytokines using Luminex xMAP technology. Lupus nephritis patients had significantly increased plasma eotaxin, TNF-α, interleukin-17-α, interleukin-10, and interleukin-15 as compared to the systemic lupus erythematosus non-nephritis group. Macrophage-derived chemokine, growth regulated oncogene alpha, and epidermal growth factor were significantly elevated in systemic lupus erythematosus non-nephritis patients when compared to lupus nephritis individuals. Plasma eotaxin levels allowed a discrimination between systemic lupus erythematosus non-nephritis and lupus nephritis patients, for which we performed a receiver operating characteristic curve to confirm. We observed a correlation of eotaxin levels with active nephritis (Systemic Lupus Erythematosus Disease Activity Index). Our data indicate that circulating cytokines and chemokines could be considered good predictors of renal involvement in individuals with systemic lupus erythematosus.</description><subject>Biomarkers</subject><subject>Biopsy</subject><subject>Chemokines</subject><subject>Cytokines</subject><subject>Eotaxin</subject><subject>Epidermal growth factor</subject><subject>Interleukin 10</subject><subject>Interleukin 15</subject><subject>Interleukin 17</subject><subject>Kidneys</subject><subject>Lupus</subject><subject>Lupus nephritis</subject><subject>Macrophage-derived chemokine</subject><subject>Morbidity</subject><subject>Nephritis</subject><subject>Plasma</subject><subject>Plasma levels</subject><subject>Regression analysis</subject><subject>Systemic lupus erythematosus</subject><subject>Tumor necrosis factor-α</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kUtL5UAQhRsZ0etj72pomI2baD_Sr6XIjAqCLnQdOp2OtjdJx1QHyb-3L1cdEFwVVH3nVHEKoRNKzihV6pwYSRnhnGpNmVRmB61oqVSR--wXWm3GxWa-jw4AXgghnBq5h_Y5KQXXVK_Q031nobfYLSmuw-ABW8BjTH5IwXa4DrG309pPgGOL16EZ_IIb29snj8OAR5tCJgG_hfSMYYHk--BwN48zYD8t6dn3NkWY4QjttrYDf_xRD9Hjv78Pl9fF7d3VzeXFbeFKolIhrDDOy1bS2kjTCCe0Y5KzljlfUycEaahTDaN1q7TRmteNaRvBOCdCMcf4ITrd-o5TfJ09pKoP4HzX2cHHGSpGuSRCmlJn9M839CXO05Cvy5QwQlBS8kyRLeWmCDD5thqnkDNZKkqqzROq70_Ikt8fxnPd--ZL8Jl6BootADnH_1t_NHwH5OKPRQ</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Pacheco-Lugo, L.</creator><creator>Sáenz-García, J.</creator><creator>Navarro Quiroz, E</creator><creator>González Torres, H.</creator><creator>Fang, L.</creator><creator>Díaz-Olmos, Y.</creator><creator>Garavito de Egea, G.</creator><creator>Egea Bermejo, E.</creator><creator>Aroca Martínez, G.</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7567-6409</orcidid><orcidid>https://orcid.org/0000-0002-9222-3257</orcidid></search><sort><creationdate>201901</creationdate><title>Plasma cytokines as potential biomarkers of kidney damage in patients with systemic lupus erythematosus</title><author>Pacheco-Lugo, L. ; Sáenz-García, J. ; Navarro Quiroz, E ; González Torres, H. ; Fang, L. ; Díaz-Olmos, Y. ; Garavito de Egea, G. ; Egea Bermejo, E. ; Aroca Martínez, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-5a59ce6f61b969d5c58c2632f2ceb1c550d1c7d21bf789883bd9fd52330572c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Biomarkers</topic><topic>Biopsy</topic><topic>Chemokines</topic><topic>Cytokines</topic><topic>Eotaxin</topic><topic>Epidermal growth factor</topic><topic>Interleukin 10</topic><topic>Interleukin 15</topic><topic>Interleukin 17</topic><topic>Kidneys</topic><topic>Lupus</topic><topic>Lupus nephritis</topic><topic>Macrophage-derived chemokine</topic><topic>Morbidity</topic><topic>Nephritis</topic><topic>Plasma</topic><topic>Plasma levels</topic><topic>Regression analysis</topic><topic>Systemic lupus erythematosus</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pacheco-Lugo, L.</creatorcontrib><creatorcontrib>Sáenz-García, J.</creatorcontrib><creatorcontrib>Navarro Quiroz, E</creatorcontrib><creatorcontrib>González Torres, H.</creatorcontrib><creatorcontrib>Fang, L.</creatorcontrib><creatorcontrib>Díaz-Olmos, Y.</creatorcontrib><creatorcontrib>Garavito de Egea, G.</creatorcontrib><creatorcontrib>Egea Bermejo, E.</creatorcontrib><creatorcontrib>Aroca Martínez, G.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pacheco-Lugo, L.</au><au>Sáenz-García, J.</au><au>Navarro Quiroz, E</au><au>González Torres, H.</au><au>Fang, L.</au><au>Díaz-Olmos, Y.</au><au>Garavito de Egea, G.</au><au>Egea Bermejo, E.</au><au>Aroca Martínez, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma cytokines as potential biomarkers of kidney damage in patients with systemic lupus erythematosus</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2019-01</date><risdate>2019</risdate><volume>28</volume><issue>1</issue><spage>34</spage><epage>43</epage><pages>34-43</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>Background
Systemic lupus erythematosus is a heterogeneous chronic inflammatory autoimmune disorder characterized by an exacerbated expression of cytokines and chemokines in different tissues and organs. Renal involvement is a significant contributor to the morbidity and mortality of systemic lupus erythematosus, and its diagnosis is based on renal biopsy, an invasive procedure with a high risk of complications. Therefore, the development of alternative, non-invasive diagnostic tests for kidney disease in patients with systemic lupus erythematosus is a priority.
Aim
To evaluate the plasma levels of a panel of cytokines and chemokines using multiplex xMAP technology in a cohort of Colombian patients with active and inactive systemic lupus erythematosus, and to evaluate their potential as biomarkers of renal involvement.
Results
Plasma from 40 systemic lupus erythematosus non-nephritis patients and 80 lupus nephritis patients with different levels of renal involvement were analyzed for 39 cytokines using Luminex xMAP technology. Lupus nephritis patients had significantly increased plasma eotaxin, TNF-α, interleukin-17-α, interleukin-10, and interleukin-15 as compared to the systemic lupus erythematosus non-nephritis group. Macrophage-derived chemokine, growth regulated oncogene alpha, and epidermal growth factor were significantly elevated in systemic lupus erythematosus non-nephritis patients when compared to lupus nephritis individuals. Plasma eotaxin levels allowed a discrimination between systemic lupus erythematosus non-nephritis and lupus nephritis patients, for which we performed a receiver operating characteristic curve to confirm. We observed a correlation of eotaxin levels with active nephritis (Systemic Lupus Erythematosus Disease Activity Index). Our data indicate that circulating cytokines and chemokines could be considered good predictors of renal involvement in individuals with systemic lupus erythematosus.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>30453818</pmid><doi>10.1177/0961203318812679</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-7567-6409</orcidid><orcidid>https://orcid.org/0000-0002-9222-3257</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Lupus, 2019-01, Vol.28 (1), p.34-43 |
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| source | SAGE Complete A-Z List |
| subjects | Biomarkers Biopsy Chemokines Cytokines Eotaxin Epidermal growth factor Interleukin 10 Interleukin 15 Interleukin 17 Kidneys Lupus Lupus nephritis Macrophage-derived chemokine Morbidity Nephritis Plasma Plasma levels Regression analysis Systemic lupus erythematosus Tumor necrosis factor-α |
| title | Plasma cytokines as potential biomarkers of kidney damage in patients with systemic lupus erythematosus |
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