Relevance of Intraoperative Pleural Lavage Cytology and Histologic Subtype in Lung Adenocarcinoma
The association between pleural lavage cytology (PLC) and histologic subtype remains unknown. In this study, we evaluated the effect of a micropapillary pattern (MPP) in lung adenocarcinomas on results of PLC. We retrospectively reviewed 600 consecutive patients with surgically resected pulmonary ad...
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| Veröffentlicht in: | The Annals of thoracic surgery 2018-12, Vol.106 (6), p.1654-1660 |
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| creator | Mikubo, Masashi Naito, Masahito Matsui, Yoshio Shiomi, Kazu Ichinoe, Masaaki Yoshida, Tsutomu Satoh, Yukitoshi |
| description | The association between pleural lavage cytology (PLC) and histologic subtype remains unknown. In this study, we evaluated the effect of a micropapillary pattern (MPP) in lung adenocarcinomas on results of PLC.
We retrospectively reviewed 600 consecutive patients with surgically resected pulmonary adenocarcinomas and investigated the relationship between PLC status and clinicopathologic factors, including a histologically identified MPP component.
PLC was positive in 25 patients (4.2%). Positive PLC was significantly associated with MPP (p = 0.0001), lymph node metastasis (p = 0.01), and pleural invasion (p < 0.0001) according to multivariate analysis. Furthermore, the presence of MPP reinforced the effect of some established predictive factors, such as large tumor size, lymph node metastasis, pleural invasion, and lymphovascular invasion, on positive PLC. Two factors—MPP and positive PLC—were associated with a higher incidence of occult N2 lymph node metastases. The prognosis of adenocarcinomas in patients with MPP or positive PLC was significantly worse than that of patients without these features. Furthermore, the survival of MPP and positive PLC group (MPP+ PLC+) was significantly worse than that of MPP and negative PLC group (MPP+ PLC−, p = 0.03).
The presence of MPP in lung adenocarcinoma can be an independent predictor of positive PLC. These two factors have complementary and synergistic roles as prognostic factors. Detailed preoperative or intraoperative examination of histologic subtype and PLC findings may provide important information for prediction of tumor progression and decisions regarding the surgical procedure. |
| doi_str_mv | 10.1016/j.athoracsur.2018.07.035 |
| format | Article |
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We retrospectively reviewed 600 consecutive patients with surgically resected pulmonary adenocarcinomas and investigated the relationship between PLC status and clinicopathologic factors, including a histologically identified MPP component.
PLC was positive in 25 patients (4.2%). Positive PLC was significantly associated with MPP (p = 0.0001), lymph node metastasis (p = 0.01), and pleural invasion (p < 0.0001) according to multivariate analysis. Furthermore, the presence of MPP reinforced the effect of some established predictive factors, such as large tumor size, lymph node metastasis, pleural invasion, and lymphovascular invasion, on positive PLC. Two factors—MPP and positive PLC—were associated with a higher incidence of occult N2 lymph node metastases. The prognosis of adenocarcinomas in patients with MPP or positive PLC was significantly worse than that of patients without these features. Furthermore, the survival of MPP and positive PLC group (MPP+ PLC+) was significantly worse than that of MPP and negative PLC group (MPP+ PLC−, p = 0.03).
The presence of MPP in lung adenocarcinoma can be an independent predictor of positive PLC. These two factors have complementary and synergistic roles as prognostic factors. Detailed preoperative or intraoperative examination of histologic subtype and PLC findings may provide important information for prediction of tumor progression and decisions regarding the surgical procedure.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/j.athoracsur.2018.07.035</identifier><identifier>PMID: 30227125</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adenocarcinoma of Lung - classification ; Adenocarcinoma of Lung - pathology ; Adenocarcinoma of Lung - surgery ; Aged ; Body Fluids - cytology ; Cytodiagnosis ; Female ; Humans ; Intraoperative Care - methods ; Lymphatic Metastasis ; Male ; Pleura - pathology ; Retrospective Studies ; Therapeutic Irrigation</subject><ispartof>The Annals of thoracic surgery, 2018-12, Vol.106 (6), p.1654-1660</ispartof><rights>2018 The Society of Thoracic Surgeons</rights><rights>Copyright © 2018 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-f9759b2f7534d558d26772c46249b7ae95c5c75cbef8c8f550cbb0f6096150093</citedby><cites>FETCH-LOGICAL-c424t-f9759b2f7534d558d26772c46249b7ae95c5c75cbef8c8f550cbb0f6096150093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30227125$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mikubo, Masashi</creatorcontrib><creatorcontrib>Naito, Masahito</creatorcontrib><creatorcontrib>Matsui, Yoshio</creatorcontrib><creatorcontrib>Shiomi, Kazu</creatorcontrib><creatorcontrib>Ichinoe, Masaaki</creatorcontrib><creatorcontrib>Yoshida, Tsutomu</creatorcontrib><creatorcontrib>Satoh, Yukitoshi</creatorcontrib><title>Relevance of Intraoperative Pleural Lavage Cytology and Histologic Subtype in Lung Adenocarcinoma</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>The association between pleural lavage cytology (PLC) and histologic subtype remains unknown. In this study, we evaluated the effect of a micropapillary pattern (MPP) in lung adenocarcinomas on results of PLC.
We retrospectively reviewed 600 consecutive patients with surgically resected pulmonary adenocarcinomas and investigated the relationship between PLC status and clinicopathologic factors, including a histologically identified MPP component.
PLC was positive in 25 patients (4.2%). Positive PLC was significantly associated with MPP (p = 0.0001), lymph node metastasis (p = 0.01), and pleural invasion (p < 0.0001) according to multivariate analysis. Furthermore, the presence of MPP reinforced the effect of some established predictive factors, such as large tumor size, lymph node metastasis, pleural invasion, and lymphovascular invasion, on positive PLC. Two factors—MPP and positive PLC—were associated with a higher incidence of occult N2 lymph node metastases. The prognosis of adenocarcinomas in patients with MPP or positive PLC was significantly worse than that of patients without these features. Furthermore, the survival of MPP and positive PLC group (MPP+ PLC+) was significantly worse than that of MPP and negative PLC group (MPP+ PLC−, p = 0.03).
The presence of MPP in lung adenocarcinoma can be an independent predictor of positive PLC. These two factors have complementary and synergistic roles as prognostic factors. Detailed preoperative or intraoperative examination of histologic subtype and PLC findings may provide important information for prediction of tumor progression and decisions regarding the surgical procedure.</description><subject>Adenocarcinoma of Lung - classification</subject><subject>Adenocarcinoma of Lung - pathology</subject><subject>Adenocarcinoma of Lung - surgery</subject><subject>Aged</subject><subject>Body Fluids - cytology</subject><subject>Cytodiagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Intraoperative Care - methods</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Pleura - pathology</subject><subject>Retrospective Studies</subject><subject>Therapeutic Irrigation</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EoqXwC8hLNgm2E8fJslRAK1UC8VhbjjMprtK42Emk_j0uLbBkNbqae-dxEMKUxJTQ7HYdq-7DOqV972JGaB4TEZOEn6Ax5ZxFGePFKRoTQpIoLQQfoQvv10Gy0D5Ho4QwJijjY6ReoIFBtRqwrfGi7ZyyW3CqMwPg5wZ6pxq8VINaAZ7tOtvY1Q6rtsJz47-V0fi1L7vdFrBp8bJvV3haQWu1ctq0dqMu0VmtGg9XxzpB7w_3b7N5tHx6XMymy0inLO2iOpxZlKwWPEkrzvOKZUIwnWYsLUqhoOCaa8F1CXWu85pzosuS1BkpMsoJKZIJujnM3Tr72YPv5MZ4DU2jWrC9l4wmPEsTKpJgzQ9W7az3Dmq5dWaj3E5SIveA5Vr-AZZ7wJIIGQCH6PVxS19uoPoN_hANhruDAcKvgwEnvTYQ-FbGge5kZc3_W74AiBmSVg</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Mikubo, Masashi</creator><creator>Naito, Masahito</creator><creator>Matsui, Yoshio</creator><creator>Shiomi, Kazu</creator><creator>Ichinoe, Masaaki</creator><creator>Yoshida, Tsutomu</creator><creator>Satoh, Yukitoshi</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201812</creationdate><title>Relevance of Intraoperative Pleural Lavage Cytology and Histologic Subtype in Lung Adenocarcinoma</title><author>Mikubo, Masashi ; Naito, Masahito ; Matsui, Yoshio ; Shiomi, Kazu ; Ichinoe, Masaaki ; Yoshida, Tsutomu ; Satoh, Yukitoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-f9759b2f7534d558d26772c46249b7ae95c5c75cbef8c8f550cbb0f6096150093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adenocarcinoma of Lung - classification</topic><topic>Adenocarcinoma of Lung - pathology</topic><topic>Adenocarcinoma of Lung - surgery</topic><topic>Aged</topic><topic>Body Fluids - cytology</topic><topic>Cytodiagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Intraoperative Care - methods</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Pleura - pathology</topic><topic>Retrospective Studies</topic><topic>Therapeutic Irrigation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mikubo, Masashi</creatorcontrib><creatorcontrib>Naito, Masahito</creatorcontrib><creatorcontrib>Matsui, Yoshio</creatorcontrib><creatorcontrib>Shiomi, Kazu</creatorcontrib><creatorcontrib>Ichinoe, Masaaki</creatorcontrib><creatorcontrib>Yoshida, Tsutomu</creatorcontrib><creatorcontrib>Satoh, Yukitoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mikubo, Masashi</au><au>Naito, Masahito</au><au>Matsui, Yoshio</au><au>Shiomi, Kazu</au><au>Ichinoe, Masaaki</au><au>Yoshida, Tsutomu</au><au>Satoh, Yukitoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relevance of Intraoperative Pleural Lavage Cytology and Histologic Subtype in Lung Adenocarcinoma</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>2018-12</date><risdate>2018</risdate><volume>106</volume><issue>6</issue><spage>1654</spage><epage>1660</epage><pages>1654-1660</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><abstract>The association between pleural lavage cytology (PLC) and histologic subtype remains unknown. In this study, we evaluated the effect of a micropapillary pattern (MPP) in lung adenocarcinomas on results of PLC.
We retrospectively reviewed 600 consecutive patients with surgically resected pulmonary adenocarcinomas and investigated the relationship between PLC status and clinicopathologic factors, including a histologically identified MPP component.
PLC was positive in 25 patients (4.2%). Positive PLC was significantly associated with MPP (p = 0.0001), lymph node metastasis (p = 0.01), and pleural invasion (p < 0.0001) according to multivariate analysis. Furthermore, the presence of MPP reinforced the effect of some established predictive factors, such as large tumor size, lymph node metastasis, pleural invasion, and lymphovascular invasion, on positive PLC. Two factors—MPP and positive PLC—were associated with a higher incidence of occult N2 lymph node metastases. The prognosis of adenocarcinomas in patients with MPP or positive PLC was significantly worse than that of patients without these features. Furthermore, the survival of MPP and positive PLC group (MPP+ PLC+) was significantly worse than that of MPP and negative PLC group (MPP+ PLC−, p = 0.03).
The presence of MPP in lung adenocarcinoma can be an independent predictor of positive PLC. These two factors have complementary and synergistic roles as prognostic factors. Detailed preoperative or intraoperative examination of histologic subtype and PLC findings may provide important information for prediction of tumor progression and decisions regarding the surgical procedure.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>30227125</pmid><doi>10.1016/j.athoracsur.2018.07.035</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma of Lung - classification Adenocarcinoma of Lung - pathology Adenocarcinoma of Lung - surgery Aged Body Fluids - cytology Cytodiagnosis Female Humans Intraoperative Care - methods Lymphatic Metastasis Male Pleura - pathology Retrospective Studies Therapeutic Irrigation |
| title | Relevance of Intraoperative Pleural Lavage Cytology and Histologic Subtype in Lung Adenocarcinoma |
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