Chemokine CXCL10/CXCR3 signaling contributes to neuropathic pain in spinal cord and dorsal root ganglia after chronic constriction injury in rats

•The expression and distribution of CXCL10 and CXCR3 in the SC and DRG following CCI.•Intrathecal injection of CXCR3 inhibitor AMG487 down-regulated p-ERK expression in CCI-induced neuropathic pain.•Inhibition of CXCR3 alleviated the pain hypersensitivity induced by CCI. Inflammatory cytokines and c...

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Veröffentlicht in:	Neuroscience letters 2019-02, Vol.694, p.20-28
Hauptverfasser:	Chen, Yonglin, Yin, Dekun, Fan, Bingbing, Zhu, Xiang, Chen, Qiuping, Li, Yao, Zhu, Shunxing, Lu, Rongxiang, Xu, Zhongling
Format:	Artikel
Sprache:	eng
Schlagworte:	Chronic constriction injury (CCI) CXCL10 CXCR3 Neuropathic pain p-ERK
Online-Zugang:	Volltext
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