Alum-functionalized graphene oxide nanocomplexes for effective anticancer vaccination

[Display omitted] Aluminum-based adjuvant (e.g., aluminum oxyhydroxide (AlO(OH), known as the commercial Alhydrogel® (Alum)) is the first adjuvant to be used in human vaccines. Although Alum shows a robust induction of antibody-mediated immunity, its weak stimulation of cell-mediated immunity makes...

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Veröffentlicht in:	Acta biomaterialia 2019-01, Vol.83, p.390-399
Hauptverfasser:	Wang, Xiaoli, Cao, Fengqiang, Yan, Mengmeng, Liu, Yijia, Zhu, Xianghui, Sun, Hongfan, Ma, Guilei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants, Immunologic - chemistry Adjuvants, Immunologic - pharmacology Alum Compounds - chemistry Alum Compounds - pharmacology Aluminum Aluminum oxyhydroxide Animals Anticancer properties Antigens Antigens, Neoplasm - chemistry Antigens, Neoplasm - immunology Antigens, Neoplasm - pharmacology Cancer Cancer immunotherapy Cancer Vaccines CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cell-mediated immunity Dendritic Cells - immunology Dendritic Cells - pathology Graphene Graphene oxide Graphite - chemistry Graphite - pharmacology Immune response Immune response (humoral) Immune system Immunity Immunity, Cellular - drug effects Immunization Immunoglobulin G Immunotherapy Lymphocytes T Melanoma, Experimental - immunology Melanoma, Experimental - pathology Melanoma, Experimental - therapy Mice Nanostructures - chemistry Nanostructures - therapeutic use Tumors Vaccine Vaccine development Vaccines
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