Discovery and optimization of 3,4,5-trimethoxyphenyl substituted triazolylthioacetamides as potent tubulin polymerization inhibitors

[Display omitted] •Based on our previous work, 29 novel triazolylthioacetamides possessing 3,4,5-trimethoxylphenyl groups were synthesized.•8f and 8j showed potent antiproliferative activities against Hela with IC50 values of 0.04 and 0.05 μM, respectively.•8b exhibited potent antitubulin activity w...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2019-01, Vol.29 (1), p.22-27
Hauptverfasser:	Yang, Fang, He, Cai-Ping, Diao, Peng-Cheng, Hong, Kwon Ho, Rao, Jin-Jun, Zhao, Pei-Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiproliferative activity Synthesis Triazolylthioacetamides Tubulin polymerization
Online-Zugang:	Volltext
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