Preventive Effects of a Kampo Medicine, Shosaikoto, on Inflammatory Responses in LPS-Treated Human Gingival Fibroblasts

In the present study, we investigated the anti-inflammatory effects of a Kampo medicine Shosaikoto (TJ-9) using in vitro periodontal disease model, in which human gingival fibroblasts (HGFs) treated with lipopolysaccharide (LPS) from Porphyromonas gingivalis (PgLPS) produce IL-6, IL-8 and prostaglan...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2008/06/01, Vol.31(6), pp.1141-1144
Hauptverfasser:	Ara, Toshiaki, Maeda, Yoshihiro, Fujinami, Yoshiaki, Imamura, Yasuhiro, Hattori, Toshimi, Wang, Pao-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal Blotting, Western Cell Survival - drug effects Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - metabolism Dinoprostone - biosynthesis Dose-Response Relationship, Drug Drugs, Chinese Herbal - pharmacology Enzyme-Linked Immunosorbent Assay Fibroblasts - drug effects Gingiva - cytology Gingiva - drug effects gingival fibroblast Gingivitis - drug therapy Gingivitis - pathology Humans Indicators and Reagents Interleukin-6 - biosynthesis Interleukin-8 - biosynthesis lipopolysaccharide Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - toxicity Macrophages - drug effects Macrophages - metabolism Medicine, Kampo Monocytes - drug effects Monocytes - metabolism periodontal disease Porphyromonas gingivalis Porphyromonas gingivalis - chemistry Shosaikoto Tetrazolium Salts Thiazoles
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