Anti-addictive properties of COR659 – Additional pharmacological evidence and comparison with a series of novel analogues

A recent study found that COR659 (methyl 2-[(4-chlorophenyl)carboxamido]-4-ethyl-5-methylthiophene-3-carboxylate) reduced operant alcohol and chocolate self-administration in rats; COR659 also suppressed cue-induced reinstatement of chocolate seeking in rats. COR659 apparently exerts its effects via...

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Veröffentlicht in:	Alcohol (Fayetteville, N.Y.) N.Y.), 2019-03, Vol.75, p.55-66
Hauptverfasser:	Maccioni, Paola, Colombo, Giancarlo, Lorrai, Irene, Fara, Federica, Carai, Mauro A.M., Gessa, Gian Luigi, Brizzi, Antonella, Mugnaini, Claudia, Corelli, Federico
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcohol Drinking - drug therapy Alcohol Drinking - metabolism Alcohol Drinking - psychology Alcohol use Alcohols Allosteric properties Animals Behavior Behavior, Addictive - drug therapy Behavior, Addictive - metabolism Behavior, Addictive - psychology Binding sites Cannabinoid CB1 receptors Chocolate COR659 Dose-Response Relationship, Drug Drug self-administration Ethanol - administration & dosage GABA Modulators - chemistry GABA Modulators - metabolism GABA Modulators - therapeutic use GABAB receptor Hypotheses Laboratories Male Operant conditioning Operant self-administration Physicochemical properties Pyridines Rat Rats Rats, Wistar Receptor, Cannabinoid, CB1 - metabolism Receptors, GABA-B - metabolism Reinforcement, Psychology Reinstatement Self Administration γ-Aminobutyric acid B receptors
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