Polymorphisms in IMPDH2, UGT2B7, and CES2 genes influence the risk of graft rejection in kidney transplant recipients taking mycophenolate mofetil

•The SNP rs11706052 (IMPDH2) showed a 4.2-fold protection against graft rejection.•The SNP rs7438135 (UGT2B7) showed a 2.4-fold protection, against graft rejection.•The SNP rs2241409 (CES2) was associated with a 7.2-fold increased risk of rejection.•SNPs in IMPDH2, UGT2B7 and CES2 genes are potentia...

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Veröffentlicht in:	Mutation research. Genetic toxicology and environmental mutagenesis 2018-12, Vol.836 (Pt B), p.97-102
Hauptverfasser:	Cilião, Heloísa Lizotti, Camargo-Godoy, Rossana Batista Oliveira, Souza, Marilesia Ferreira de, Zanuto, Amanda, Delfino, Vinicius Daher Alvares, Cólus, Ilce Mara de Syllos
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid mycophenolic Allelic variants Antibiotics, Antineoplastic - adverse effects Carboxylesterase - genetics Drug transporter gene Female Genotype Glucuronosyltransferase - genetics Graft Rejection - etiology Graft Rejection - pathology Humans IMP Dehydrogenase - genetics Kidney Transplantation - adverse effects Male Metabolism gene Middle Aged Mycophenolic Acid - adverse effects Polymorphism, Genetic Rejection episodes Renal transplantation
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