Increasing complexity in oncology phase I clinical trials

Summary Clinical trials in oncology have become increasingly complex because of incorporation of predictive biomarkers and patient selection based on molecular profiling of tumors. We have examined the change in procedures and work intensity in phase 1 oncology trials over the years with several par...

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Veröffentlicht in:	Investigational new drugs 2019-06, Vol.37 (3), p.519-523
Hauptverfasser:	Malik, Laeeq, Lu, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers Blood cancer Cancer Clinical trials Clinical Trials, Phase I as Topic - standards Complexity Hematology Humans Immunotherapy Invasiveness Laboratories Laboratory tests Maximum Tolerated Dose Medical research Medicine Medicine & Public Health Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - pathology Oncology Patient Selection Pharmacology Pharmacology/Toxicology Physical examinations Prognosis Research Design - standards Short Report Studies Subjective assessment Tissue Distribution Tumors
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