MicroRNA‐99a‐5p suppresses breast cancer progression and cell‐cycle pathway through downregulating CDC25A

In this study, we aimed to explore the association between miR‐99a‐5p and CDC25A in breast cancer and the regulatory mechanisms of miR‐99a‐5p on breast cancer. The expressions of messenger RNA and microRNAs in breast cancer tissues and adjacent tissues were analyzed by the Cancer Genome Atlas microa...

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Veröffentlicht in:	Journal of cellular physiology 2019-04, Vol.234 (4), p.3526-3537
Hauptverfasser:	Qin, Hongzhen, Liu, Wenfei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Apoptosis Assaying BAX protein Bioinformatics Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer cdc25 Phosphatases - genetics cdc25 Phosphatases - metabolism CDC25A Cell Cycle Cell growth Cell Movement Cell Proliferation cell‐cycle pathway Cyclin D1 Cyclin D1 - genetics Cyclin D1 - metabolism Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Disease Progression Down-Regulation Female Flow cytometry Gelatinase A Gelatinase B Gene Expression Regulation, Neoplastic Genomes GTP-binding protein Humans Ki-67 Antigen - genetics Ki-67 Antigen - metabolism MCF-7 Cells Mice, Nude MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miRNA miR‐99a‐5p mRNA Neoplasm Invasiveness Polymerase chain reaction Proteins Regulatory mechanisms (biology) Ribonucleic acid RNA Signal Transduction Transfection Transplantation Tumor Burden
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