Nasal allergen-neutralizing IgG4 antibodies block IgE-mediated responses: Novel biomarker of subcutaneous grass pollen immunotherapy

Grass pollen subcutaneous immunotherapy (SCIT) is associated with induction of serum IgG4-associated inhibitory antibodies that prevent IgE-facilitated allergen binding to B cells. We sought to determine whether SCIT induces nasal allergen-specific IgG4 antibodies with inhibitory activity that corre...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2019-03, Vol.143 (3), p.1067-1076
Hauptverfasser:	Shamji, Mohamed H., Kappen, Jasper, Abubakar-Waziri, Hisham, Zhang, Jinjin, Steveling, Esther, Watchman, Shelley, Kouser, Lubna, Eifan, Aarif, Switzer, Amy, Varricchi, Gilda, Marone, Gianni, Couto-Francisco, Natália C., Calderon, Moises, Durham, Stephen R.
Format:	Artikel
Sprache:	eng
Schlagworte:	allergic rhinoconjunctivitis with and without asthma Biomarkers of allergen immunotherapy blocking antibodies IgA1 IgA2 IgE-facilitated allergen binding IgG4 subcutaneous immunotherapy
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