Selective Labeling Aldehydes in DNA

A naphthalimide hydroxylamine probe has been designed and synthesized to selectively label the whole natural aldehydes present in DNAs including 5-formylcytosine, 5-formyluracil, and abasic sites. The fluorescence characteristics of the generated nucleosides have been examined in detail, and the rea...

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Veröffentlicht in:	Analytical chemistry (Washington) 2018-12, Vol.90 (24), p.14616-14621
Hauptverfasser:	Liu, Chaoxing, Luo, Xiaomeng, Chen, Yuqi, Wu, Fan, Yang, Wei, Wang, Yafen, Zhang, Xiong, Zou, Guangrong, Zhou, Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Analytical chemistry Chemistry Deoxyribonucleic acid DNA Fluorescence Hydroxylamine Labeling Organic chemistry
Online-Zugang:	Volltext
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