A review discussing the use of polyethylene glycol microspheres in the treatment of hepatocellular carcinoma
Transarterial chemoembolization (TACE) is indicated in unresectable hepatocellular carcinoma and allows the delivery of embolics inside tumor vascularization to reduce blood supply and release gradually the drug. This lowers the systemic exposure to chemotherapeutics, while increasing their local co...
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| Veröffentlicht in: | Future oncology (London, England) England), 2019-03, Vol.15 (7), p.695-703 |
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| creator | Fiorentini, Giammaria Sarti, Donatella Carandina, Riccardo Mulazzani, Luca Mincarelli, Cinzia Candelari, Roberto Argirò, Renato Fiorentini, Caterina Aliberti, Camillo |
| description | Transarterial chemoembolization (TACE) is indicated in unresectable hepatocellular carcinoma and allows the delivery of embolics inside tumor vascularization to reduce blood supply and release gradually the drug. This lowers the systemic exposure to chemotherapeutics, while increasing their local concentration and tissue necrosis that is higher than conventional TACE. The technology of TACE has seen the introduction of several types of embolics that are made of different materials. Available embolics for TACE include: drug-eluting beads (DC beads), acrylic copolymer,
-acrylic microspheres and polyethylene glycol (PEG) microspheres. Few studies are available on PEG embolics and their use for TACE. This review focuses on the efficacy and safety of TACE performed with PEG microspheres for the treatment of hepatocellular carcinoma and discusses future therapeutic advantages. |
| doi_str_mv | 10.2217/fon-2018-0425 |
| format | Article |
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-acrylic microspheres and polyethylene glycol (PEG) microspheres. Few studies are available on PEG embolics and their use for TACE. 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This lowers the systemic exposure to chemotherapeutics, while increasing their local concentration and tissue necrosis that is higher than conventional TACE. The technology of TACE has seen the introduction of several types of embolics that are made of different materials. Available embolics for TACE include: drug-eluting beads (DC beads), acrylic copolymer,
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| subjects | Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - adverse effects Antibiotics, Antineoplastic - chemistry Carcinoma, Hepatocellular - therapy Chemoembolization, Therapeutic Doxorubicin - administration & dosage Doxorubicin - adverse effects Doxorubicin - chemistry Drug Delivery Systems Drug dosages Drug Evaluation Humans Libraries Liver cancer Liver Neoplasms - therapy Microspheres Particle Size Patients PEG Polyethylene glycol polyethylene glycol microspheres Polyethylene Glycols - administration & dosage Polyethylene Glycols - adverse effects Polyethylene Glycols - chemistry Polyvinyl alcohol safety Survival analysis transarterial chemoembolization hepatocellular carcinoma Treatment Outcome treatment response Tumors |
| title | A review discussing the use of polyethylene glycol microspheres in the treatment of hepatocellular carcinoma |
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