REFRACTORY GASTRIC ANTRAL ULCER OF UNKNOWN ETIOLOGY

We report a Helicobacter pylori‐negative patient with multiple gastric antral ulcers of unknown etiology and without a history of taking non‐steroidal anti‐inflammatory drugs (NSAIDs). The patient was a 68‐year‐old woman, and her serum gastrin and pepsinogen levels were within normal limits. The antral ulcers were refractory to treatment with a proton pump inhibitor (PPI) or an H2 receptor antagonist alone. However, since nocturnal gastric acid breakthrough was observed, both drugs were given in combination, which resulted in the healing of the ulcers.