Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts

Insulin promotes the translocation of glucose transporter 4 (GLUT4) from intracellular pools to the surface of muscle and fat cells via a mechanism dependent on phosphatidylinositol (PtdIns) 3-kinase, actin cytoskeletal remodeling and the v-SNARE VAMP2. The growth factor PDGF-BB also robustly activa...

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Veröffentlicht in:	Journal of cell science 2004-10, Vol.117 (Pt 22), p.5447-5455
Hauptverfasser:	Török, Dòra, Patel, Nish, Jebailey, Lellean, Thong, Farah S L, Randhawa, Varinder K, Klip, Amira, Rudich, Assaf
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - chemistry Actins - metabolism Animals Cell Line Cytoskeleton - metabolism Exocytosis Glucose - metabolism Glucose Transporter Type 4 Immunoblotting Insulin - metabolism Insulin Resistance Membrane Proteins - metabolism Microscopy, Fluorescence Monosaccharide Transport Proteins - metabolism Muscle Proteins - metabolism Muscles - metabolism Phosphatidylinositol 3-Kinases - metabolism Platelet-Derived Growth Factor - metabolism Protein Transport Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt R-SNARE Proteins Rats Tetanus Toxin - pharmacology Time Factors Transfection Vesicle-Associated Membrane Protein 3
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