Serine integrase recombinational engineering (SIRE): A versatile toolbox for genome editing

Chromosomal integration of biosynthetic pathways for the biotechnological production of high‐value chemicals is a necessity to develop industrial strains with a high long‐term stability and a low production variability. However, the introduction of multiple transcription units into the microbial gen...

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Veröffentlicht in:	Biotechnology and bioengineering 2019-02, Vol.116 (2), p.364-374
Hauptverfasser:	Snoeck, Nico, De Mol, Maarten L., Van Herpe, Dries, Goormans, Anke, Maryns, Isabelle, Coussement, Pieter, Peters, Gert, Beauprez, Joeri, De Maeseneire, Sofie L., Soetaert, Wim
Format:	Artikel
Sprache:	eng
Schlagworte:	Baking yeast Biosynthetic Pathways - genetics E coli Engineering Escherichia coli Escherichia coli - genetics Gene Editing - methods Genome editing Genomes Genomic Instability genomic integration Industrial strains Integrase Integrases - metabolism knock‐in Metabolic Engineering - methods Microorganisms Mutagenesis, Insertional - methods Operons Organic chemistry PhiC31 Recombinase Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Selectivity Serine serine integrase Transcription
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